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Kcna3  -  potassium channel, voltage gated shaker...

Rattus norvegicus

Synonyms: Potassium voltage-gated channel subfamily A member 3, RCK3, RGK5, Voltage-gated potassium channel subunit Kv1.3, Voltage-gated potassium channel subunit Kv3
 
 
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High impact information on Kcna3

  • Injections of RNA combinations (RBK1/RBK2 and RBK1/RGK5) caused currents that had TEA sensitivities different from those expected from the sum, in any proportion, of the two native channels [1].
  • RCK3 and RCK4 mRNAs are present throughout all developmental stages studied [2].
  • RNA transcribed in vitro from RGK5 genomic DNA directs the expression of functional potassium currents after injection into Xenopus oocytes [3].
  • RGK5 transcripts are present in both mouse thymus and rat brain, as determined by Northern blot analysis [3].
  • Low stringency hybridization screening of a rat genomic DNA library with a previously described cDNA clone encoding a rat voltage-gated potassium channel has resulted in the characterization of a member of the potassium channel family, RGK5 [3].
 

Anatomical context of Kcna3

  • Functional similarities with the microglial outwardly rectifying K+ channel were found in the Kn-channel of lymphocytes which has recently been cloned (RGK5) [4].
  • The polymerase chain reaction (PCR) was used to demonstrate the presence of RGK5-like mRNA in microglia [4].

References

  1. Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits. Christie, M.J., North, R.A., Osborne, P.B., Douglass, J., Adelman, J.P. Neuron (1990) [Pubmed]
  2. Members of the RCK potassium channel family are differentially expressed in the rat nervous system. Beckh, S., Pongs, O. EMBO J. (1990) [Pubmed]
  3. Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel. Douglass, J., Osborne, P.B., Cai, Y.C., Wilkinson, M., Christie, M.J., Adelman, J.P. J. Immunol. (1990) [Pubmed]
  4. Expression of an outwardly rectifying K+ channel in rat microglia cultivated on teflon. Nörenberg, W., Appel, K., Bauer, J., Gebicke-Haerter, P.J., Illes, P. Neurosci. Lett. (1993) [Pubmed]
 
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