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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hip1r  -  huntingtin interacting protein 1 related

Mus musculus

Synonyms: AA410023, HIP1-related protein, Huntingtin-interacting protein 1-related protein, mKIAA0655
 
 
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Disease relevance of Hip1r

  • Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1 [1].
 

High impact information on Hip1r

  • Consistent with a functional role for Hip1R in endocytosis, we also demonstrated that it promotes clathrin cage assembly in vitro [2].
  • Finally, we showed that Hip1R is a rod-shaped apparent dimer with globular heads at either end, and that it can assemble clathrin-coated vesicles and F-actin into higher order structures [2].
  • Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo [3].

References

  1. Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1. Hyun, T.S., Li, L., Oravecz-Wilson, K.I., Bradley, S.V., Provot, M.M., Munaco, A.J., Mizukami, I.F., Sun, H., Ross, T.S. Mol. Cell. Biol. (2004) [Pubmed]
  2. The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro. Engqvist-Goldstein, A.E., Warren, R.A., Kessels, M.M., Keen, J.H., Heuser, J., Drubin, D.G. J. Cell Biol. (2001) [Pubmed]
  3. Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. Chen, C.Y., Brodsky, F.M. J. Biol. Chem. (2005) [Pubmed]
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