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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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About

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Gene Review: 

Rpl3  -  ribosomal protein L3

Rattus norvegicus

Synonyms: 60S ribosomal protein L3, L4
 
 
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High impact information on Rpl3

  • Using quantitative laser scanning photostimulation we measured the strength of excitatory projections from layer 4 (L4) and L5A to L2/3 pyramidal cells in barrel- and septum-related columns [1].
  • We measured spike trains from neurons in layer 4 (L4) and layers 2 and 3 (L2/3) of rat somatosensory cortex before and after acute whisker deprivation, a manipulation that induces whisker map plasticity involving LTD at L4-to-L2/3 (L4-L2/3) synapses [2].
  • The results suggest that each connected L4 spiny neurone produces a weak but reliable EPSP in the pyramidal cell [3].
  • Antisense oligonucleotides to L4 mRNA inhibit neurite regeneration from the differentiated PC12 cells as well as axonal elongation from conditioned sensory neurons, indicating that ongoing translation of L4 mRNA is needed for these forms of rapid transcription-independent neurite growth [4].
  • The amino acid sequences of the rat 60S ribosomal subunit proteins L4 and L41 were deduced from the sequences of nucleotides in recombinant cDNAs [5].
 

Biological context of Rpl3

 

Anatomical context of Rpl3

  • Here we show that whisker deprivation, a manipulation that drives map plasticity in rat somatosensory cortex (S1), induces detectable LTD-like depression at intracortical excitatory synapses between cortical layer 4 (L4) and L2/3 pyramidal neurons [6].
 

Analytical, diagnostic and therapeutic context of Rpl3

References

  1. Geometric and functional organization of cortical circuits. Shepherd, G.M., Stepanyants, A., Bureau, I., Chklovskii, D., Svoboda, K. Nat. Neurosci. (2005) [Pubmed]
  2. Modulation of spike timing by sensory deprivation during induction of cortical map plasticity. Celikel, T., Szostak, V.A., Feldman, D.E. Nat. Neurosci. (2004) [Pubmed]
  3. Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column. Feldmeyer, D., Lübke, J., Silver, R.A., Sakmann, B. J. Physiol. (Lond.) (2002) [Pubmed]
  4. Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration. Twiss, J.L., Smith, D.S., Chang, B., Shooter, E.M. Neurobiol. Dis. (2000) [Pubmed]
  5. The primary structures of rat ribosomal proteins L4 and L41. Chan, Y.L., Olvera, J., Wool, I.G. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  6. Long-term depression induced by sensory deprivation during cortical map plasticity in vivo. Allen, C.B., Celikel, T., Feldman, D.E. Nat. Neurosci. (2003) [Pubmed]
  7. Spatiotemporal evolution of excitation and inhibition in the rat barrel cortex investigated with multielectrode arrays. Wirth, C., Lüscher, H.R. J. Neurophysiol. (2004) [Pubmed]
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