The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

dld  -  deltaD

Danio rerio

Synonyms: After eight protein, Delta-like protein D, DeltaD, SO:0000704, aei
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on dld

  • Our study focuses on how the oscillations in the expression of these two genes is affected in the mutants aei/deltaD and des/notch1, in 'morpholino knockdowns' of deltaC and her1 and in double 'mutant' combinations [1].
  • Germline transformation using a minigene comprising 10.5 kb of this genomic DNA attached to the 3' end of a full-length cDNA clone rescues the phenotype of embryos homozygous for the amorphic deltaD mutation after eight(AR33) [2].
  • We have analysed the organisation of the regulatory region of the deltaD gene using fusions to the reporter gene gfp and germline transgenesis [2].
  • During gastrulation, hypochord precursors are closely associated with no tail-expressing midline precursors and paraxial mesoderm, which expresses deltaC and deltaD [3].
  • In accordance with its functional role, deltaD is transcribed in several domains of mesodermal and ectodermal origin during embryogenesis [2].
 

Biological context of dld

 

Anatomical context of dld

  • We show that deltaC, deltaD, and notch1 are expressed in the marginal domain of blastula stage embryos and that this expression is dependent on Nodal signaling [5].
  • This neurogenic defect correlates with reduced levels of expression of deltaA and deltaD in the hair cells in no isthmus mutants [6].
  • These properties imply that competitive lateral inhibition, mediated by coordinated activities of deltaA, deltaB and deltaD, is sufficient to explain how primary neurons emerge from proneural clusters of neuroepithelial cells in the zebrafish [7].
  • Inhibition of Hedgehog-induced slow muscle induction in aei/deltaD and deadly seven (des)/notch1a mutant embryos suggests that slow muscle is necessary for myotome boundary recovery in the absence of initial epithelial somite boundary formation [8].
  • Because we have previously demonstrated that slow muscle migration triggers fast muscle cell elongation in zebrafish, we hypothesize that migrating slow muscle facilitates myotome boundary formation in aei/deltaD mutant embryos by patterning coordinated fast muscle cell elongation [8].
 

Other interactions of dld

  • In deltaD (dlD) deficient after-eight zebrafish mutants, the dynamic expression of hey1 in the PSM is impaired and completely lost in newly formed somitomeres [9].
  • We find that mutations in zebrafish integrinalpha5 disrupt anterior somite formation, giving a phenotype complementary to the posterior defects seen in the notch pathway mutants after eight/deltaD and deadly seven/notch1a [10].
  • In the neural plate, deltaA and deltaD, unlike Delta1 in tetrapods, are expressed in large patches of contiguous cells, within which scattered individuals expressing deltaB become singled out as primary neurons [7].

References

  1. her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis. Holley, S.A., Jülich, D., Rauch, G.J., Geisler, R., Nüsslein-Volhard, C. Development (2002) [Pubmed]
  2. On the organisation of the regulatory region of the zebrafish deltaD gene. Hans, S., Campos-Ortega, J.A. Development (2002) [Pubmed]
  3. Delta-Notch signaling induces hypochord development in zebrafish. Latimer, A.J., Dong, X., Markov, Y., Appel, B. Development (2002) [Pubmed]
  4. The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis. Sieger, D., Tautz, D., Gajewski, M. Mech. Dev. (2003) [Pubmed]
  5. Notch signaling can regulate endoderm formation in zebrafish. Kikuchi, Y., Verkade, H., Reiter, J.F., Kim, C.H., Chitnis, A.B., Kuroiwa, A., Stainier, D.Y. Dev. Dyn. (2004) [Pubmed]
  6. The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1. Riley, B.B., Chiang, M., Farmer, L., Heck, R. Development (1999) [Pubmed]
  7. Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis. Haddon, C., Smithers, L., Schneider-Maunoury, S., Coche, T., Henrique, D., Lewis, J. Development (1998) [Pubmed]
  8. Interactions between muscle fibers and segment boundaries in zebrafish. Henry, C.A., McNulty, I.M., Durst, W.A., Munchel, S.E., Amacher, S.L. Dev. Biol. (2005) [Pubmed]
  9. Characterization of hey bHLH genes in teleost fish. Winkler, C., Elmasri, H., Klamt, B., Volff, J.N., Gessler, M. Dev. Genes Evol. (2003) [Pubmed]
  10. Integrinalpha5 and delta/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis. Jülich, D., Geisler, R., Holley, S.A. Dev. Cell (2005) [Pubmed]
 
WikiGenes - Universities