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Gene Review

isl2b  -  ISL LIM homeobox 2b

Danio rerio

Synonyms: ISL-3, Insulin gene enhancer protein isl-2b, Insulin gene enhancer protein isl-3, Islet-2B, Islet-3, ...
 
 
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High impact information on isl2b

  • These data, combined with the results of mosaic analyses, suggest that Islet-3 is activated by putative LIM-binding cofactors and functions to promote evagination of the optic vesicles and to maintain reciprocal interaction between the mesencephalon and the mesencephalic-metencephalic boundary essential for normal development of this region [1].
  • Islet-3 is an LIM/homeodomain protein that is expressed specifically in the eyes and the presumptive tectum in the central nervous system of zebrafish (Danio rerio) embryos [1].
  • The level of isl-1 mRNA is generally higher than those of isl-2 and isl-3 mRNAs [2].
  • This suggests that zfIsl-3 may be involved in the regional specification of the myotome and also in target recognition by CaP. zfIsl-2 is also expressed throughout the developing eye and tectal region of the midbrain, the target for the retinal axons [3].
  • We therefore searched for genes that may be either up- or down-regulated by overexpression of LIM(Isl-3) by comparing the gene expression profiles in the midbrain and the MHB of normal embryos and embryos in which Islet-3 function was repressed, using a combination of ordered differential display and whole-mount in situ hybridization [4].
 

Analytical, diagnostic and therapeutic context of isl2b

  • Southern blot analysis of genomic DNA indicate that they are derived from three distinct genes, designated as isl-2a, isl-2b, and isl-3 genes [2].

References

 
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