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Dnpep  -  aspartyl aminopeptidase

Rattus norvegicus

 
 
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High impact information on Dnpep

  • Decrease in cytosolic Aspartyl-aminopeptidase but not in Alanyl-aminopeptidase activity in the frontal cortex of the aged rat [1].
  • To test the neurotoxic hypothesis of excitatory amino acids, we evaluated the possible contribution to the free acidic amino acid pool of Aspartyl-aminopeptidase activity in the frontal cortex of adult (3 month old) and aged rats (3 groups of animals aged 26, 29 and 33 months) [1].
  • These diurnal variations in aspartyl aminopeptidase activity could reflect the functional status of its putative endogenous substrates, such as angiotensin II, and it may also suggest the existence of differential regulatory mechanisms associated with each location [2].
  • The levels of specific soluble aspartyl aminopeptidase activity were assayed in retina, occipital cortex, anterior pituitary, posterior pituitary, pineal gland and serum of adult male rats, using Asp-2-naphthylamide as substrate, in a 12:12 h light:dark cycle (7-19 h light) [2].
  • Glutamyl- but not aspartyl-aminopeptidase activity is modified in serum of N-methyl nitrosourea-induced rat mammary tumours [3].
 

Anatomical context of Dnpep

 

Other interactions of Dnpep

References

  1. Decrease in cytosolic Aspartyl-aminopeptidase but not in Alanyl-aminopeptidase activity in the frontal cortex of the aged rat. Iribar, C., Esteban, M.J., Martinez, J.M., Peinado, J.M. Brain Res. (1995) [Pubmed]
  2. Daily rhythm of aspartate aminopeptidase activity in the retina, pineal gland and occipital cortex of the rat. Ramírez, M., Sánchez, B., Aréchaga, G., Lardelli, P., Venzon, D., García, S., Ozaita, A., de Gandarias, J.M. Neuroendocrinology (1992) [Pubmed]
  3. Glutamyl- but not aspartyl-aminopeptidase activity is modified in serum of N-methyl nitrosourea-induced rat mammary tumours. Carrera, M.P., Ramírez-Expósito, M.J., Valenzuela, M.T., García, M.J., Mayas, M.D., Martínez-Martos, J.M. Anticancer Res. (2004) [Pubmed]
  4. Activities of aminopeptidases in a rat saline model of volume hypertension. Prieto, I., Martinez, A., Martinez, J.M., Ramírez, M.J., Vargas, F., Alba, F., Ramírez, M. Horm. Metab. Res. (1998) [Pubmed]
  5. Oleate, linoleate and cholesterol differently modify aspartyl- and glutamyl-aminopeptidase activities in primary cultures of rat astrocytes. Ramírez-Expósito, M.J., Martínez-Martos, J.M., Mayas, M.D., García, M.J., Prieto, I., Aréchaga, G., Ramírez, M. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2001) [Pubmed]
 
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