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Gene Review:

vrrA - hypervariable Bacillus group-specific protein

Bacillus cereus E33L

Shangkuan, Y.H. et al., Zahner, V. et al., Andersen, G.L. et al.

Shangkuan, Yang, Lin, Shaio, Zahner, Cabral, Régua-Mangia, Rabinovitch, Moreau, McIntosh,

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Disease relevance of vrrA

Distribution of genes encoding putative virulence factors and fragment length polymorphisms in the vrrA gene among Brazilian isolates of Bacillus cereus and Bacillus thuringiensis [1].

High impact information on vrrA

The sequence variation was primarily in vrrA, which was glutamine- and proline-rich (30% of total) and contained repetitive regions [2].

Analytical, diagnostic and therapeutic context of vrrA

PCR-RFLP analysis of the vrrA gene and cerAB gene was used to investigate the genomic diversity in 21 strains of Bacillus anthracis and 28 strains of Bacillus cereus, and was compared with results obtained by ribotyping and enterobacterial repetitive intergenic consensus-PCR (ERIC-PCR) analysis [3].

References

Distribution of genes encoding putative virulence factors and fragment length polymorphisms in the vrrA gene among Brazilian isolates of Bacillus cereus and Bacillus thuringiensis. Zahner, V., Cabral, D.A., Régua-Mangia, A.H., Rabinovitch, L., Moreau, G., McIntosh, D. Appl. Environ. Microbiol. (2005) [Pubmed]
Identification of a region of genetic variability among Bacillus anthracis strains and related species. Andersen, G.L., Simchock, J.M., Wilson, K.H. J. Bacteriol. (1996) [Pubmed]
Comparison of PCR-RFLP, ribotyping and ERIC-PCR for typing Bacillus anthracis and Bacillus cereus strains. Shangkuan, Y.H., Yang, J.F., Lin, H.C., Shaio, M.F. J. Appl. Microbiol. (2000) [Pubmed]

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