Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

mdka - midkine a

Danio rerio

Synonyms: SO:0000704, fb05b02, mdk1, plei1, wu:fb05b02, ...

Winkler, C. et al.

Winkler, Schafer, Duschl, Schartl, Volff,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on mdka

These data indicate that mdka and mdkb underwent functional divergence after duplication [1].
In contrast to the ubiquitous expression of their mammalian counterpart, zebrafish mdka and mdkb are expressed in spatially restricted, mostly nonoverlapping patterns during embryonic development and strongly in distinct domains in the adult brain [1].

Biological context of mdka

Zebrafish mdka and mdkb genes map to linkage groups LG7 and LG25, respectively, both presenting synteny to human chromosome 11, in which the unique human ortholog mdk is located [1].

References

Functional divergence of two zebrafish midkine growth factors following fish-specific gene duplication. Winkler, C., Schafer, M., Duschl, J., Schartl, M., Volff, J.N. Genome Res. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg