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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

her3  -  hairy-related 3

Danio rerio

Synonyms: SO:0000704
 
 
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High impact information on her3

  • These data indicate that her3 and her9 function as prepattern genes that link the positional dorsoventral polarity information in the posterior neuroectoderm to the spatial regulation of neurogenesis [1].
  • In all territories, the her3 transcription domain encompasses regions in which neurogenin 1 (neurog1) is not transcribed, suggesting regulatory interactions between the two genes [2].
  • Surprisingly, and in sharp contrast to other members of the E(spl) gene family, transcription of her3 is repressed rather than activated by Notch signalling [2].
 

Other interactions of her3

  • We have examined interrelationships of her3 with members of the Notch signalling pathway by the Gal4-UAS technique and mRNA injections [2].

References

  1. Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm. Bae, Y.K., Shimizu, T., Hibi, M. Development (2005) [Pubmed]
  2. her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling. Hans, S., Scheer, N., Riedl, I., v Weizsäcker, E., Blader, P., Campos-Ortega, J.A. Development (2004) [Pubmed]
 
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