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Gene Review:

pcdh8 - protocadherin 8

Danio rerio

Synonyms: SO:0000704, papc, zPAPC

Yamamoto, A. et al., Topczewska, J.M. et al., Komoike, Y. et al., Murakami, T. et al., Sawada, A. et al., et al.

Murakami, Hijikata, Matsukawa, Ishikawa, Yorifuji,

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High impact information on pcdh8

In contrast, the expression of other genes, including mesp-a and papc, in the anterior of somite primordia, and the oscillating expression of deltaC and deltaD in the PSM appear normal [1].
These embryos show a reduction in expression of the posterior genes, myoD and notch5, with uniform expression of the anterior genes, FGFR1, papc and notch6 [2].
Further, we show that the floating head homeobox gene is required in axial mesoderm to repress the expression of both spadetail and papc, promoting notochord and blocking differentiation of paraxial mesoderm [3].
Zebrafish paraxial protocadherin (papc) encodes a transmembrane cell adhesion molecule (PAPC) expressed in trunk mesoderm undergoing morphogenesis [3].
The domain of papc transcription in somite 0 starts broad and becomes progressively restricted to the anterior edge [4].

Anatomical context of pcdh8

Comparative studies showed that pcdh10 expression lasted up to approximately three times longer in maturing somites than that of paraxial protocadherin (pcdh8) [5].
In addition, cells expressing mRNAs for no tail, spadetail, myoD, and papc, which are involved in FGF-related development of posterior mesoderm, were distributed abnormally [6].

Analytical, diagnostic and therapeutic context of pcdh8

Microinjection studies with a dominant-negative secreted construct suggest that papc is required for proper dorsal convergence movements during gastrulation [3].

References

The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. Topczewska, J.M., Topczewski, J., Shostak, A., Kume, T., Solnica-Krezel, L., Hogan, B.L. Genes Dev. (2001) [Pubmed]
Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Sawada, A., Fritz, A., Jiang, Y.J., Yamamoto, A., Yamasu, K., Kuroiwa, A., Saga, Y., Takeda, H. Development (2000) [Pubmed]
Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm. Yamamoto, A., Amacher, S.L., Kim, S.H., Geissert, D., Kimmel, C.B., De Robertis, E.M. Development (1998) [Pubmed]
The protocadherin papc is involved in the organization of the epithelium along the segmental border during mouse somitogenesis. Rhee, J., Takahashi, Y., Saga, Y., Wilson-Rawls, J., Rawls, A. Dev. Biol. (2003) [Pubmed]
Zebrafish protocadherin 10 is involved in paraxial mesoderm development and somitogenesis. Murakami, T., Hijikata, T., Matsukawa, M., Ishikawa, H., Yorifuji, H. Dev. Dyn. (2006) [Pubmed]
Zebrafish Polycomb group gene ph2alpha is required for epiboly and tailbud formation acting downstream of FGF signaling. Komoike, Y., Kawamura, A., Shindo, N., Sato, C., Satoh, J., Shiurba, R., Higashinakagawa, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]

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pcdh8.2	Xenopus (Silurana) tropicalis
LOC100498368	Xenopus (Silurana) tropicalis

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