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Gene Review:

sox11a - SRY (sex determining region Y)-box 11a

Danio rerio

Synonyms: SO:0000704, cb237, id:ibd2104, wu:fb16g02, zgc:136533

de Martino, S. et al.

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High impact information on sox11a

For example, zebrafish sox11a is expressed in the anterior somites, and zebrafish sox11b is expressed in the posterior somites, but the single Sox11 gene of mouse is expressed in all the somites [1].
Expression patterns of zebrafish sox11a and sox11b confirm that they are expressed in the developing nervous system, including the forebrain, midbrain, hindbrain, eyes, and ears from an early stage [1].
The sox11a and sox11b genes map to linkage groups 17 and 20, respectively, together with other loci whose orthologues are syntenic with human SOX11, suggesting that during the fish lineage, a large chromosome region sharing conserved syntenies with mammals has become duplicated [1].

Biological context of sox11a

In a gene phylogeny, both sox11a and sox11b cluster with human, mouse, chick, and Xenopus Sox11, indicating that zebrafish, like Xenopus, has two orthologues of tetrapod Sox11 [1].

Other interactions of sox11a

The two sox genes, sox11a and sox11b, are expressed in both overlapping and distinct sites [1].

References

Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development. de Martino, S., Yan, Y.L., Jowett, T., Postlethwait, J.H., Varga, Z.M., Ashworth, A., Austin, C.A. Dev. Dyn. (2000) [Pubmed]

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