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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

psmb8  -  proteasome (prosome, macropain) subunit,...

Danio rerio

Synonyms: SO:0000704, lmp7, psmb8a
 
 
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High impact information on psmb8

  • Analysis of a 26-kb region linked to the Mhc in zebrafish: genomic organization of the proteasome component beta/transporter associated with antigen processing-2 gene cluster and identification of five new proteasome beta subunit genes [1].
  • As a step toward achieving this goal, a commercially available zebrafish BAC library was screened with probes specific for previously identified zebrafish class I and class II genes, as well as for genes controlling the proteasome subunits LMP7 and LMP2 [2].
  • The ligand dependent degradation is completely blocked by treatment with the proteasome inhibitor, MG-132 [3].
  • Both the PA28-alpha and PA28-beta subunits are inducible by interferon-gamma (IFN-gamma) and the PA28-(alphabeta)3 complex enhances the ability of the 20S proteasome to produce peptides suited for binding to major histocompatibility complex (Mhc) class I molecules [4].
  • The ScanProsite search indicated that the deduced amino acid sequence from the flounder LMP7 contains a proteasome beta-type subunit signature, which is well conserved during evolution [5].

References

  1. Analysis of a 26-kb region linked to the Mhc in zebrafish: genomic organization of the proteasome component beta/transporter associated with antigen processing-2 gene cluster and identification of five new proteasome beta subunit genes. Murray, B.W., Sültmann, H., Klein, J. J. Immunol. (1999) [Pubmed]
  2. Analysis of zebrafish Mhc using BAC clones. Graser, R., Vincek, V., Takami, K., Klein, J. Immunogenetics (1998) [Pubmed]
  3. Ligand-dependent and -independent degradation of the human aryl hydrocarbon receptor (hAHR) in cell culture models. Pollenz, R.S., Buggy, C. Chem. Biol. Interact. (2006) [Pubmed]
  4. Identification and linkage of the proteasome activator complex PA28 subunit genes in zebrafish. Murray, B.W., Sültmann, H., Klein, J. Scand. J. Immunol. (2000) [Pubmed]
  5. CDNA for an immune response gene encoding low molecular weight polypeptide from flounder, Paralichthys olivaceus. Cho, J.J., Sung, B.K., Lee, J.H., Chung, J.K., Choi, T.J., Kim, Y.T. Mol. Cells (2001) [Pubmed]
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