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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

fabp2  -  fatty acid binding protein 2, intestinal

Danio rerio

Synonyms: I-FABP, SO:0000704, ifabp, zgc:92264
 
 
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High impact information on fabp2

  • Intestinal-type fatty acid binding protein (I-FABP) plays an important role in the intracellular binding and trafficking of long chain fatty acids in the intestine [1].
  • Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas [2].
  • In contrast to the transferrin and ifabp mRNAs, elastaseB mRNAs were not expressed in the yolk sac or YSL, and these transcripts were detected exclusively in the exocrine pancreas after approximately 56 hpf [2].
  • Functional dissection of a 41-bp region within this 192-bp promoter revealed that one C/EBP and two GATA-like binding sites, along with a novel 15-bp element within it are required for I-FABP gene expression in vivo [1].
  • I-fabp expression in the anterior intestine of the fed larvae is correlated with an intracellular storage of lipid droplets in the enterocytes and the massive synthesis of very low-density lipoprotein particles [3].
 

Biological context of fabp2

 

Anatomical context of fabp2

  • I-FABP mRNA levels were very low in muscle, testis, heart, liver, skin and ovary [4].
  • Expression in YSL, liver or pancreas has not been previously reported for fish or mammalian I-FABP genes and may be related to specific physiological differences between fishes and mammals [4].
 

Analytical, diagnostic and therapeutic context of fabp2

References

  1. Functional conserved elements mediate intestinal-type fatty acid binding protein (I-FABP) expression in the gut epithelia of zebrafish larvae. Her, G.M., Yeh, Y.H., Wu, J.L. Dev. Dyn. (2004) [Pubmed]
  2. Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas. Mudumana, S.P., Wan, H., Singh, M., Korzh, V., Gong, Z. Dev. Dyn. (2004) [Pubmed]
  3. Intestinal fatty acid binding protein gene expression reveals the cephalocaudal patterning during zebrafish gut morphogenesis. André, M., Ando, S., Ballagny, C., Durliat, M., Poupard, G., Briançon, C., Babin, P.J. Int. J. Dev. Biol. (2000) [Pubmed]
  4. Sequence, linkage mapping and early developmental expression of the intestinal-type fatty acid-binding protein gene (fabp2) from zebrafish (Danio rerio). Sharma, M.K., Denovan-Wright, E.M., Degrave, A., Thisse, C., Thisse, B., Wright, J.M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2004) [Pubmed]
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