Disease relevance of Cttnbp2

• The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis [1].
• However, analysis of rabbit ileal loops revealed that the N16961 orf4 mutant is hypervirulent, causing increased serosal hemorrhage and reactogenicity compared to its parent [2].
• The protein encoded by ORF 4 of mouse hepatitis virus (MHV) is not required for growth of some strains in tissue culture cells, but its role in pathogenesis in the murine host has not been defined previously in a controlled manner [3].

High impact information on Cttnbp2

• These data suggest that ORF3, and to a lesser degree ORF4, may affect agr expression by modulating SarA protein expression [4].
• The mutant could be complemented in vivo with an orf4 gene on a plasmid but not with an orf4 gene containing a site-directed mutation in the putative zinc metalloprotease motif [2].
• Of those tested, the sstABCD and sirABC operons and the fhuD2 and orf4 genes were found to have Fur-regulated expression [5].
• But we could not definitively confirm the ORF5-ORF4 terminator [6].
• Sequencing analysis of the S (S1 portion), HE, ORF4 and ORF5 genes of BCoV isolates associated with different clinical syndromes indicated that neither insertions or deletions could explain their distinct tropism [7].

Biological context of Cttnbp2

• In addition, a potential role of upstream ORFs (uORFs) was detected as stressed by the enhances translation of a construct mutated in uORF3 overlapping ORF4 [8].

Anatomical context of Cttnbp2

• End-phosphorothioated ORF4 (ORF4-PE) significantly reduced TNF-alpha mRNA levels by greater than 80% (p < 0.001) and protein levels by 60% (p < 0.001) in U937 cells [9].

Associations of Cttnbp2 with chemical compounds

• ORF3 is positioned in tandem with ORF5-ORF4, but has its own transcriptional start, a thymidine [6].

References