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Gene Review:

Itgb2 - integrin, beta 2

Rattus norvegicus

Inoue, S. et al., Kriegsman, J. et al.

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Disease relevance of Itgb2

LFA-1 (CD11a/CD18) and ICAM-1 (CD54) antibodies attenuate superoxide anion release from polymorphonuclear leukocytes in rats with experimental acute pancreatitis [1].
Expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction [2].

Chemical compound and disease context of Itgb2

The inhibitive effects of anti-CD11a/CD18 (LFA-1) and anti-CD54 (ICAM-1) antibodies on the generation of superoxide anion (O2-) by polymorphonuclear leukocytes (PMNs) was elucidated in rats induced with experimental acute pancreatitis [1].

References

LFA-1 (CD11a/CD18) and ICAM-1 (CD54) antibodies attenuate superoxide anion release from polymorphonuclear leukocytes in rats with experimental acute pancreatitis. Inoue, S., Nakao, A., Kishimoto, W., Murakami, H., Harada, A., Nonami, T., Takagi, H. Pancreas (1996) [Pubmed]
Expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction. Kriegsman, J., Müller, H., Sommer, M., Stiller, K., Bräuer, R., Petrow, P.K., Gaumann, A., Fünfstück, R.D., Stein, G. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2000) [Pubmed]

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