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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

tw  -  Protein O-mannosyltransferase 2

Drosophila melanogaster

Synonyms: CG12311, DPOMT2, DmPOMT2, Dmel\CG12311, Dolichyl-phosphate-mannose--protein mannosyltransferase 2, ...
 
 
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High impact information on Pomt2

  • Moreover, dPOMT2 interacted genetically with dPOMT1, suggesting that the dPOMTs function in collaboration with each other in vivo [1].
  • As humans have a second POMT, POMT2, we cloned each Drosophila ortholog of the human POMT genes and carried out RNA interference (RNAi) knock-down to investigate the function of these proteins in vivo [1].
  • A detailed characterization of the mammalian POMT2, with emphasis on mouse Pomt2, shows that mammalian POMT2 is predominantly expressed in testis tissue [2].
 

Biological context of Pomt2

  • Drosophila POMT2 (dPOMT2) RNAi mutant flies showed a "twisted abdomen phenotype," in which the abdomen is twisted 30-60 degrees , similar to the dPOMT1 mutant [1].
 

Other interactions of Pomt2

References

  1. The twisted abdomen phenotype of Drosophila POMT1 and POMT2 mutants coincides with their heterophilic protein O-mannosyltransferase activity. Ichimiya, T., Manya, H., Ohmae, Y., Yoshida, H., Takahashi, K., Ueda, R., Endo, T., Nishihara, S. J. Biol. Chem. (2004) [Pubmed]
  2. Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids. Willer, T., Amselgruber, W., Deutzmann, R., Strahl, S. Glycobiology (2002) [Pubmed]
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