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Gene Review:

icmS - hypothetical protein

Legionella pneumophila str. Lens

Zusman, T. et al., Segal, G. et al., Segal, G. et al., Albers, U. et al., Zamboni, D.S. et al.

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Disease relevance of icmS

The Coxiella dotB, icmS and icmW products restored dot/icm-dependent growth of Legionella mutants in eukaryotic host cells [1].

High impact information on icmS

The C. burnetii icmS and icmW homologous genes were found to complement the corresponding L. pneumophila icm mutants to wild-type levels of intracellular growth in both HL-60-derived human macrophages and Acanthamoeba castellanii [2].
Three genes (icmS, -G, and -F) were found to be partially required, and two genes (lphA and tphA) were found to be dispensable for intracellular growth and killing of human macrophages [3].
However, this gene was found to be required for macrophage killing, since a kanamycin resistance cassette introduced into icmS by gene replacement resulted in a mutant that was attenuated for macrophage killing [4].
An icmS suppressor plasmid was isolated that harboured the icmS and flanking icm genes, indicating that this plasmid complements the intracellular growth defect of the mutant [5].

References

Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system. Zamboni, D.S., McGrath, S., Rabinovitch, M., Roy, C.R. Mol. Microbiol. (2003) [Pubmed]
Functional similarities between the icm/dot pathogenesis systems of Coxiella burnetii and Legionella pneumophila. Zusman, T., Yerushalmi, G., Segal, G. Infect. Immun. (2003) [Pubmed]
Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages. Segal, G., Shuman, H.A. Infect. Immun. (1999) [Pubmed]
Characterization of a new region required for macrophage killing by Legionella pneumophila. Segal, G., Shuman, H.A. Infect. Immun. (1997) [Pubmed]
The amoebae plate test implicates a paralogue of lpxB in the interaction of Legionella pneumophila with Acanthamoeba castellanii. Albers, U., Reus, K., Shuman, H.A., Hilbi, H. Microbiology (Reading, Engl.) (2005) [Pubmed]

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