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dotA  -  defect in organelle trafficking protein DotA

Legionella pneumophila str. Lens

 
 
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Disease relevance of dotA

  • Knockout of dotA, a central gene involved in type IVB secretion, did not alter IL-8 induction, whereas lack of flagellin significantly reduced IL-8 release by Legionella [1].
 

High impact information on dotA

  • Following encystment in Acanthamoeba castellanii and reversion of cysts to amoeba trophozoites, dotA and dotB mutants exhibited intracellular multiplication in amoebae [2].
 

Anatomical context of dotA

  • Following incubation of stationary-phase cultures in water, mutants in dotA and dotB, essential for function of the type IVB secretion system, exhibited entry and delay of phagosome acidification comparable to that of strain JR32 [2].

References

  1. Legionella pneumophila-induced NF-{kappa}B- and MAPK-dependent cytokine release by lung epithelial cells. Schmeck, B., N'guessan, P.D., Ollomang, M., Lorenz, J., Zahlten, J., Opitz, B., Flieger, A., Suttorp, N., Hippenstiel, S. Eur. Respir. J. (2007) [Pubmed]
  2. Environmental mimics and the Lvh type IVA secretion system contribute to virulence-related phenotypes of Legionella pneumophila. Bandyopadhyay, P., Liu, S., Gabbai, C.B., Venitelli, Z., Steinman, H.M. Infect. Immun. (2007) [Pubmed]
 
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