Disease relevance of Bmyc

• Immunostaining of human lymphoma cells transiently transfected with a B-myc expression vector showed that the protein was mainly localized to the nucleus [1].

High impact information on Bmyc

• B-myc inhibits neoplastic transformation and transcriptional activation by c-myc [2].
• B-myc is a recently described myc gene whose product has not been functionally characterized [2].
• We describe the cloning of a new member of the myc family from rat genomic and cDNA libraries, designated B-myc [3].
• B-myc mapped to rat chromosome 3 [3].
• A fragment of cloned B-myc was used to map the corresponding rat locus by Southern blotting of DNA prepared from rat X mouse somatic cell hybrids [3].

Biological context of Bmyc

• To confirm the putative open reading frame, we have produced a trpE-Bmyc protein that is detected with a pan-myc antibody [4].
• Nucleotide sequence of the rat Bmyc gene [4].
• Recombinant plasmid expressing the entire coding region of the Bmyc putative protein [5].
• An expression vector with the entire coding region of Bmyc oncogene was constructed [5].

Anatomical context of Bmyc

• Here, we show that high level B-myc expression is restricted to specific mouse tissues, primarily hormonally-controlled tissues, with the highest level of expression in the epididymis [6].

Other interactions of Bmyc

• The predicted product of B-myc is a 168-amino-acid protein with extensive homology to the c-Myc amino-terminal region, previously shown to contain a transcriptional activation domain [2].

References