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Gene Review

Bmyc  -  brain expressed myelocytomatosis oncogene

Rattus norvegicus

Synonyms: B-myc, Mycb, Protein B-Myc
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Disease relevance of Bmyc

  • Immunostaining of human lymphoma cells transiently transfected with a B-myc expression vector showed that the protein was mainly localized to the nucleus [1].

High impact information on Bmyc


Biological context of Bmyc


Anatomical context of Bmyc

  • Here, we show that high level B-myc expression is restricted to specific mouse tissues, primarily hormonally-controlled tissues, with the highest level of expression in the epididymis [6].

Other interactions of Bmyc


  1. Mouse and rat B-myc share amino acid sequence homology with the c-myc transcriptional activator domain and contain a B-myc specific carboxy terminal region. Asker, C.E., Magnusson, K.P., Piccoli, S.P., Andersson, K., Klein, G., Cole, M.D., Wiman, K.G. Oncogene (1995) [Pubmed]
  2. B-myc inhibits neoplastic transformation and transcriptional activation by c-myc. Resar, L.M., Dolde, C., Barrett, J.F., Dang, C.V. Mol. Cell. Biol. (1993) [Pubmed]
  3. Structure and expression of B-myc, a new member of the myc gene family. Ingvarsson, S., Asker, C., Axelson, H., Klein, G., Sümegi, J. Mol. Cell. Biol. (1988) [Pubmed]
  4. Nucleotide sequence of the rat Bmyc gene. Asker, C., Steinitz, M., Andersson, K., Sümegi, J., Klein, G., Ingvarsson, S. Oncogene (1989) [Pubmed]
  5. Recombinant plasmid expressing the entire coding region of the Bmyc putative protein. Steinitz, M., Ingvarsson, S., Asker, C., Sümegi, J., Klein, G. Journal of clinical & laboratory immunology. (1990) [Pubmed]
  6. B-Myc is preferentially expressed in hormonally-controlled tissues and inhibits cellular proliferation. Gregory, M.A., Xiao, Q., Cornwall, G.A., Lutterbach, B., Hann, S.R. Oncogene (2000) [Pubmed]
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