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Gene Review:

dwg - deformed wings

Drosophila melanogaster

Synonyms: CG2711, CG2714, DWG, Dmel\CG2711, EG:95B7.6, ...

Kropat, J. et al., Gaszner, M. et al., Blanton, J. et al., Moon, H. et al.

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High impact information on dwg

We show that the Drosophila scs and scs' boundary proteins, Zw5 and BEAF, respectively, interact with each other in vitro and in vivo [1].
Multiple copies of an oligonucleotide containing the SBP recognition sequence are capable of blocking enhancer-promoter interactions in transgene assays [2].
A regulator of nutritional copper signaling in Chlamydomonas is an SBP domain protein that recognizes the GTAC core of copper response element [3].
The SBP domain of Chlamydomonas Crr1 binds also to a related GTAC-containing sequence in the Arabidopsis AP1 promoter that is the binding site of a defining member of the SBP family of DNA-binding proteins [3].

Biological context of dwg

Four proteins have been identified in Drosophila mediating enhancer blocking-Su(Hw), Zw5, BEAF32 and GAGA factor [4].

References

Protein:protein interactions and the pairing of boundary elements in vivo. Blanton, J., Gaszner, M., Schedl, P. Genes Dev. (2003) [Pubmed]
The Zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction. Gaszner, M., Vazquez, J., Schedl, P. Genes Dev. (1999) [Pubmed]
A regulator of nutritional copper signaling in Chlamydomonas is an SBP domain protein that recognizes the GTAC core of copper response element. Kropat, J., Tottey, S., Birkenbihl, R.P., Depège, N., Huijser, P., Merchant, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. Moon, H., Filippova, G., Loukinov, D., Pugacheva, E., Chen, Q., Smith, S.T., Munhall, A., Grewe, B., Bartkuhn, M., Arnold, R., Burke, L.J., Renkawitz-Pohl, R., Ohlsson, R., Zhou, J., Renkawitz, R., Lobanenkov, V. EMBO Rep. (2005) [Pubmed]

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