Disease relevance of HMI

• We report a patient with mental retardation, behavioral disturbances, and pigmentary anomalies, consistent with the phenotype of hypomelanosis of Ito (HMI), and in whom cytogenetic analysis revealed mosaicism for an unbalanced translocation [1].
• They were divided into two groups: (1) multiple trauma patients without head injury (MI group, n = 21); and (2) multiple trauma patients with severe head injury (HMI group, n = 21) [2].
• Immune sera from 15 patients with cured amoebic liver abscess were used to recognise the antigens of Entamoeba histolytica (HMI) by immunoblotting [3].
• Lifetime sexual behaviors were examined among two samples of predominantly minority, male adolescents in New York City aged 12 to 18 (M = 16.3), believed to be at high risk for HIV infection: 59 runaway males in two residential shelters and 60 males attending a community agency (HMI) for gay and bisexual youths [4].
• In this period 12 mothers and two fathers of patients contracted acute hepatitis B with overt jaundice three to 14 months after their offspring had IPA [5].

Psychiatry related information on HMI

• This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease [6].
• OBJECTIVE: To report on the feasibility and psychometric properties in terms of homogeneity and construct validity of a newly developed handicap questionnaire focusing on person-perceived handicaps: the Impact on Participation and Autonomy (IPA) [7].
• While many HMOs and insurance companies have contracted with outside managed mental health firms to control mental health utilization, ConnectiCare, an IPA Model HMO with nearly 100,000 members, manages its own mental health utilization with a multifaceted approach [8].
• Transcripts were analysed employing IPA and four major themes identified: Uncertainty/Trying to understand, Implications, Ways of coping and Self-concept/Identity [9].
• Developing treatment algorithms for unipolar depression in Cyberspace: International Psychopharmacology Algorithm Project (IPAP) [10].

High impact information on HMI

• Ordered genotypes: an extended ITO method and a general formula for genetic covariance [11].
• The transient outward current (ITO) is an important repolarizing component of the cardiac action potential [12].
• A channel recently cloned from human ventricular myocardium (Kv1.4, HK1) produces a rapidly inactivating K+ current, which has phenotypic similarities to the 4-aminopyridine-sensitive component of ITO [12].
• In native cardiac myocytes, ITO is modulated after activation of protein kinase C, although the molecular nature of this effect is not well understood [12].
• Human T lymphocytes that proliferate in the presence of conditioned medium from PHA-stimulated allogeneic peripheral blood cells were shown to express IPA antigens after the 8th culture day [13].

Chemical compound and disease context of HMI

• The Cooperative German Paediatric Liver Tumour Study HB89 was conceived to evaluate the efficiency and toxicity of ifosfamide, cisplatin and doxorubicin (IPA) in children with resectable and non-resectable hepatoblastoma (HB) and to determine late sequelae including tubular nephropathy of tumour treatment [14].
• Surgical biopsy performed after the first IPA (ifosfamide, cisplatin, doxorubicin) course showed hepatoblastoma with macrotrabecular variant [15].
• DATA SOURCES: MEDLINE (1966-April 2003), IPA (1970-April 2003), and EMBASE (1974-April 2003) with search terms of ACE inhibitor, angiotensin receptor blocker, essential hypertension, and combination therapy [16].
• The bioconversion of high concentration isopropanol (2-propanol, IPA) was investigated by a solvent tolerant strain of bacteria, which was identified as Sphingobacterium mizutae ST2 by partial 16S rDNA gene sequencing [17].
• Light-harvesting antenna core (LH1-RC) complexes isolated from Rhodospirillum rubrum and Rhodopseudomonas palustris were successfully self-assembled on an ITO electrode modified with 3-aminopropyltriethoxysilane [18].

Biological context of HMI

• However, hepatic glucose production and whole body lipolysis rates were significantly decreased in HMI patients [2].
• A review of the published report with chromosome mosaicism and hypomelanosis of Ito (HMI) is included [19].
• First the ITO and gold electrodes modified chemically with SAMs of porphyrins with a spacer of the same number of atoms were prepared to compare the effects of energy transfer (EN) quenching of the porphyrin excited singlet states by the two electrodes [20].
• We believe that the dramatic differences in electron-transfer kinetics observed at the various ITO films can be attributed to either the different density of defect sites along the grain boundaries or defect sites caused by substitutional Sn in the film [21].
• External application of TEA blocked ITO with an IC50 of 1 mM [22].

Anatomical context of HMI

• T-lymphocytes, stimulated with phytohaemagglutinin (PHA), were progressively cytotoxic for virulent HMI amoebae over 18 h incubation, but were also reduced in viability themselves [23].
• Ninety-one hearts explanted during 1997-2001 were examined to determine the extent of adipose tissue within HMI [24].
• The location of the HMI, the age and gender of the patient, age of HMI, and whether the patient was treated with coronary artery bypass surgery (CABG) were noted [24].
• 4. These results provide the necessary functional support for the hypothesis that Kv4.2 is a major isoform contributing to cardiac ITO, consistent with independent biochemical and molecular evidence that indicates that Kv4.2 is readily detected in rat myocytes [25].
• IPA, IMT and ITIC passed the blood-brain barrier, and thereafter showed efflux from the brain [26].

Associations of HMI with chemical compounds

• Glutamine release, which forms a significant net release of brain amino acids in normal subjects may be impaired in HMI patients [2].
• The hydride complexes [MH(kappa(2)-MI)(CO)(PPh(3))(2)](M = Ru, Os) were obtained from the reaction of HMI and KOH with [RuHCl(CO)(PPh(3))(3)] and [OsHCl(CO)(BTD)(PPh(3))(2)], respectively [27].
• The in situ hydroruthenation of 1-ethynylcyclohexan-1-ol by [RuH(CO)Cl(BTD)(PPh(3))(2)] and subsequent addition of the HMI ligand and excess sodium methoxide yielded the dehydrated 1,3-dienyl complex [Ru(CH=CHC(6)H(9))(kappa(2)-MI)(CO)(PPh(3))(2)] [27].
• An in vitro serologic assay for HDI sensitivity was developed by immunizing guinea pigs with HDI and with hexyl isocyanate (HMI) [28].
• The thiocarbonyl complex [Ru(CPh = CHPh)Cl(CS)(PPh(3))(2)] reacted with HMI and NaOMe without migration to yield [Ru(CPh= CHPh)(kappa(2)-MI)(CS)(PPh(3))(2)], while treatment of [Ru(CH=CHPh)Cl(CO)(2)(PPh(3))(2)] with HMI yielded the monodentate acyl product [Ru{eta(1)-C(=O)CH=CHPh}(kappa(2)-MI)(CO)(PPh(3))(2)] [27].

Other interactions of HMI

• In a study of community psychiatric practice, a sample of 53 patients with no medical comorbidity (NMI) was compared with 50 patients, categorized by higher (HMI) or lower (LMI) levels of physical comorbidity, approximately 5 months after beginning treatment for a current episode of major depression [29].

Analytical, diagnostic and therapeutic context of HMI

• To examine this problem, five trained males (VO2peak = 4.00 +/- 0.27 l.min-1) performed 45 min of moderate intensity (MI, 127 W) and high-moderate intensity (HMI, 166 W) cycle ergometry both at pedal rates of 60 rpm and 90 rpm [30].
• Using a radioimmunoassay (RAST), antibodies reacted with conjugates containing either HDI or HMI as haptens [28].
• The topography of the 'highest' IPA, i.e. the maximal cerebral blood flow (CBF) change between ictal and interictal SPECT, significantly colocalized with the site of onset of the discharge, and that of the lower IPAs with that of the area of propagation (P < 0.0001) [31].
• The surface structures of H(2)P and H(2)P-C(60) SAMs on ITO (H(2)P/ITO and H(2)P-C(60)/ITO) have been observed successfully in molecular resolution with atomic force microscopy for the first time [20].
• In conclusion, IPA chemotherapy in combination with delayed surgery was highly effective in the treatment of HB [14].

References