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Gene Review:

Eomes - eomesodermin

Rattus norvegicus

Russ, A.P. et al., Sahgal, N. et al.

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High impact information on LOC316052

Eomesodermin is required for mouse trophoblast development and mesoderm formation [1].
In the embryo proper, Eomesodermin is essential for mesoderm formation [1].
Mouse embryos lacking Eomesodermin arrest at the blastocyst stage [1].
DMSO treatment had a striking stimulatory effect on eomesodermin expression and a reciprocal inhibitory effect on Hand1 expression [2].

Anatomical context of LOC316052

Our results indicate that Eomesodermin defines a conserved molecular pathway controlling the morphogenetic movements of germ layer formation and has acquired a new function in mammals in the differentiation of trophoblast [1].
Mutant trophoectoderm does not differentiate into trophoblast, indicating that Eomesodermin may be required for the development of trophoblast stem cells [1].

References

Eomesodermin is required for mouse trophoblast development and mesoderm formation. Russ, A.P., Wattler, S., Colledge, W.H., Aparicio, S.A., Carlton, M.B., Pearce, J.J., Barton, S.C., Surani, M.A., Ryan, K., Nehls, M.C., Wilson, V., Evans, M.J. Nature (2000) [Pubmed]
Modulation of trophoblast stem cell and giant cell phenotypes: analyses using the Rcho-1 cell model. Sahgal, N., Canham, L.N., Konno, T., Wolfe, M.W., Soares, M.J. Differentiation (2005) [Pubmed]

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EOMES	Bos taurus
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eomesa	Danio rerio
EOMES	Gallus gallus
EOMES	Homo sapiens
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eomes	Xenopus (Silurana) tropicalis

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