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Gene Review:

TTHA1965 - inorganic pyrophosphatase

Thermus thermophilus HB8

Satoh, T. et al., Höhne, W.E. et al., Obmolova, G. et al., Teplyakov, A. et al.

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Disease relevance of TTHA1965

Crystal structure of inorganic pyrophosphatase from Thermus thermophilus [1].

High impact information on TTHA1965

The genomic DNA encoding the inorganic pyrophosphatase from an extremely thermophilic bacterium, Thermus thermophilus HB8 (ATCC27634), was isolated by colony hybridization with a probe designed as a part of gene amplified by the PCR method, which was derived from the partial amino acid sequence of the enzyme [2].
The inorganic pyrophosphatase from T. thermophilus exhibits extremely high thermostability which is decreased by addition of EDTA indicating a stabilizing effect of divalent metal ions [3].

Analytical, diagnostic and therapeutic context of TTHA1965

Molecular cloning, expression, and site-directed mutagenesis of inorganic pyrophosphatase from Thermus thermophilus HB8 [2].
Purification, crystallization and preliminary X-ray analysis of inorganic pyrophosphatase from Thermus thermophilus [4].

References

Crystal structure of inorganic pyrophosphatase from Thermus thermophilus. Teplyakov, A., Obmolova, G., Wilson, K.S., Ishii, K., Kaji, H., Samejima, T., Kuranova, I. Protein Sci. (1994) [Pubmed]
Molecular cloning, expression, and site-directed mutagenesis of inorganic pyrophosphatase from Thermus thermophilus HB8. Satoh, T., Samejima, T., Watanabe, M., Nogi, S., Takahashi, Y., Kaji, H., Teplyakov, A., Obmolova, G., Kuranova, I., Ishii, K. J. Biochem. (1998) [Pubmed]
Kinetic characterization of a thermostable inorganic pyrophosphatase from Thermus thermophilus. Höhne, W.E., Wessner, H., Kuranova, I.P., Obmolova, G.V. Biomed. Biochim. Acta (1988) [Pubmed]
Purification, crystallization and preliminary X-ray analysis of inorganic pyrophosphatase from Thermus thermophilus. Obmolova, G., Kuranova, I., Teplyakov, A. J. Mol. Biol. (1993) [Pubmed]

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