Gene Review:
HMGCL - 3-hydroxymethyl-3-methylglutaryl-CoA lyase
Bos taurus
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High impact information on HMGCL
- However, the data suggest that the cleavage of HMG-CoA is at least partially reversible and indicate that enolization of acetyl-CoA may be dependent upon a conformational change of HMG-CoA lyase, induced by binding of acetoacetate, in a manner analogous to the keto acid dependent tritium exchange catalyzed by malate synthase and citrate synthase [1].
- While 3-hydroxyglutaryl-CoA does not appear to be a substrate for HMG-CoA lyase, it competitively inhibits both the cleavage reaction (Ki = 50 microM) and the tritium exchange from acetyl-CoA (Ki = 95 microM) [1].
References
- 3-hydroxy-3-methylglutaryl-CoA lyase: catalysis of acetyl coenzyme A enolization. Kramer, P.R., Miziorko, H.M. Biochemistry (1983) [Pubmed]
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