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Gene Review:

cikA - two-component sensor kinase

Synechococcus elongatus PCC 6301

Schmitz, O. et al., Mutsuda, M. et al.

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Disease relevance of cikA

We recently described the cikA (circadian input kinase A) gene, whose product supplies environmental information to the circadian oscillator in the cyanobacterium Synechococcus elongatus PCC 7942 [1].

High impact information on cikA

Inactivation of the gene cikA (circadian input kinase) shortens the circadian period of gene expression rhythms in S. elongatus by approximately 2 hours, changes the phasing of a subset of rhythms, and nearly abolishes resetting of phase by a pulse of darkness [2].

References

Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942. Mutsuda, M., Michel, K.P., Zhang, X., Montgomery, B.L., Golden, S.S. J. Biol. Chem. (2003) [Pubmed]
CikA, a bacteriophytochrome that resets the cyanobacterial circadian clock. Schmitz, O., Katayama, M., Williams, S.B., Kondo, T., Golden, S.S. Science (2000) [Pubmed]

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