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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Zdhhc17  -  zinc finger, DHHC domain containing 17

Mus musculus

Synonyms: A230053P19Rik, BB187739, D130071N24Rik, DHHC-17, Hip14, ...
 
 
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High impact information on Zdhhc17

  • The palmitoylation and distribution of htt are regulated by the palmitoyl transferase huntingtin interacting protein 14 (HIP14) [1].
  • Downregulation of HIP14 in mouse neurons expressing wild-type and mutant htt increases inclusion formation, whereas overexpression of HIP14 substantially reduces inclusions [1].
 

Associations of Zdhhc17 with chemical compounds

  • Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase [2].
 

Analytical, diagnostic and therapeutic context of Zdhhc17

  • Characterization of HIP14 in mouse cells has revealed that it has the ability to induce colony formation in cell culture, anchorage-independent growth, and tumors in mice [2].

References

  1. Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Yanai, A., Huang, K., Kang, R., Singaraja, R.R., Arstikaitis, P., Gan, L., Orban, P.C., Mullard, A., Cowan, C.M., Raymond, L.A., Drisdel, R.C., Green, W.N., Ravikumar, B., Rubinsztein, D.C., El-Husseini, A., Hayden, M.R. Nat. Neurosci. (2006) [Pubmed]
  2. Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. Ducker, C.E., Stettler, E.M., French, K.J., Upson, J.J., Smith, C.D. Oncogene (2004) [Pubmed]
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