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Gene Review

HOXA6  -  homeobox A6

Homo sapiens

Synonyms: HOX1, HOX1.2, HOX1B, Homeobox protein Hox-1B, Homeobox protein Hox-A6
 
 
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Disease relevance of HOXA6

 

High impact information on HOXA6

  • In the current studies, we sequenced and characterized the gene for the homeodomain protein (hox1) in a bipolar mushroom, Pholiota nameko, which is a putative homologue of A mating type genes in the tetrapolar basidiomycete, Coprinopsis cinerea [2].
  • RESULTS: The HOX-1 genotypes were classified into two groups: group I were individuals with class L allele (the number of GT = 32 repeats), and group II were those without class L allele (the number of GT < 32 repeats) [1].
  • The finished sequence from BAC clones from the genome of the sea urchin, Strongylocentrotus purpuratus, reveals a gene order wherein the anterior genes (Hox1, Hox2 and Hox3) lie nearest the posterior genes in the cluster such that the most 3' gene is Hox5 [3].
 

Analytical, diagnostic and therapeutic context of HOXA6

  • Identification and linkage mapping of the genes for the putative homeodomain protein (hox1) and the putative pheromone receptor protein homologue (rcb1) in a bipolar basidiomycete, Pholiota nameko [2].

References

  1. Heme oxygenase-1 polymorphism associated with severity of chronic obstructive pulmonary disease. Fu, W.P., Zhao, Z.H., Fang, L.Z., Sun, C., Liu, L., Zhang, J.Q., Zhang, Y.P., Dai, L.M. Chin. Med. J. (2007) [Pubmed]
  2. Identification and linkage mapping of the genes for the putative homeodomain protein (hox1) and the putative pheromone receptor protein homologue (rcb1) in a bipolar basidiomycete, Pholiota nameko. Aimi, T., Yoshida, R., Ishikawa, M., Bao, D., Kitamoto, Y. Curr. Genet. (2005) [Pubmed]
  3. Unusual gene order and organization of the sea urchin hox cluster. Cameron, R.A., Rowen, L., Nesbitt, R., Bloom, S., Rast, J.P., Berney, K., Arenas-Mena, C., Martinez, P., Lucas, S., Richardson, P.M., Davidson, E.H., Peterson, K.J., Hood, L. J. exp. zool. B. Mol. Dev. Evol. (2006) [Pubmed]
 
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