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Gene Review

Ten-a  -  Tenascin accessory

Drosophila melanogaster

Synonyms: 1.2, CG11270, CG12720, CG15733, CG18182, ...
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Disease relevance of Ten-a


High impact information on Ten-a

  • Another insertion, located 1.2 kb upstream from the transcribed region of the gene, causes a mutant phenotype yet surprisingly has no obvious effect on the structure or abundance of the major white RNA [3].
  • The parent construct supported 18- to 20-fold amplification, and contained the 320 bp ACE3, the approximately 1.2 kb S18 chorion gene and the 840 bp ori-beta [4].
  • (7) 5' to the RNA start sites (1.2 kb of melanogaster DNA and 1.8 kb of virilis DNA), 17 small (9-52 base pairs) regions are evolutionarily conserved (greater than 80% sequence conservation) [5].
  • The enzyme displays positive cooperativity in phosphate buffer, a Hill number of 2.1, but only slight cooperativity in Tris buffer, a Hill number of 1.2 [6].
  • In addition, we find a pseudogene 1.2 kb upstream from Adh-2, which is transcribed in a temporal pattern similar to Adh-2 [7].

Biological context of Ten-a

  • Expression of Drosophila Ten-a, a dimeric receptor during embryonic development [8].
  • It is therefore not possible to class any of the vertebrate teneurins with either Drosophila Ten-a or Ten-m. The C-terminal part of all teneurins harbours 26 repetitive sequence motifs termed YD-repeats [9].
  • RESULTS: In lymphoblasts from patients with CLS, PMA-stimulated CREBtide phosphorylation was increased 1.2- to 2.7-fold over baseline, compared to an average fourfold increase in controls [10].
  • The Drosophila yakuba lineage shows a less extreme elevation of GC content distributed over a wider genetic region ( approximately 1.2 Mb) [11].
  • The remaining approximately 1.2 Mb, which constitutes the banded region (101E-102F) on salivary gland polytene chromosomes and contains the identified genes, is the region mapped in this study [12].

Anatomical context of Ten-a

  • Here, we report complete cDNA cloning and protein expression patterns of Ten-a. The Ten-a protein, a dimeric receptor of about 500 kDa is mainly expressed on axons of the embryonic central nervous system and on muscle attachment sites [8].
  • Homologous tissue-specific transcripts of a size of 1.2 x 10(3) base-pairs were found in testes [13].
  • Deletion of the 7.4 kb fragment to 1.2 kb resulted in a dramatic reduction of X-gal staining in the peripheral nervous system (PNS) [14].
  • Several lines that were transformed with 1.2 kb or 0.8 kb of 5' flanking DNA demonstrated relatively normal expression in sensory neuropil [15].
  • In contrast, 1.2 kb or 0.8 kb transformants showed reduced levels of expression and a more limited pattern of distribution in the optic lobe [15].

Associations of Ten-a with chemical compounds

  • From the pH dependence of the reactivity of the active site histidine to diethyl dicarbonate, we observed a pK(a) change of 1.2 units to the acid side when the enzyme undergoes the allosteric T to R transition during which the side chain of Glu148 moves toward the active site [16].
  • Consistent with typical characteristics of inward rectifiers, the K+ currents in Trp4-expressing cells were blocked by low millimolar concentrations of Cs+ and Ba2+, but not by 1.2 mM Ca2+, and were only slightly inhibited by 5 mM tetraethylammonium [17].
  • 4. Pentobarbitone directly activated the human alpha 3 beta 1 gamma 2L receptor with an EC50 of 1.2 +/- 0.03 mM and had a maximal effect amounting to 3.3 +/- 0.4 fold of the response evoked by the EC10 concentration of GABA [18].
  • Treatment of larvae with ethylnitrosourea (ENU) resulted in a dose-dependent increase of the mutation frequency to 4.8 +/- 0.6 x 10(-4) for 0.5 mM and 6.9 +/- 1.2 x 10(-4) for 1 mM ENU, respectively [19].
  • For TBBPA and TBP 5-d effective median concentration (EC50) values for inhibition of the larval development rate were 125 and 810 microg/L, respectively, whereas the PBDEs were much more potent with 5-d EC50 in the low microg/L range (1.2 microg/L for BDE-100; 4.2 microg/L for BDE-99; 13 microg/L for BDE-28; and 13 microg/L for BDE-47) [20].

Other interactions of Ten-a

  • Ten-a and Ten-m are the two Drosophila members of the newly discovered Ten-m family of dimeric type II transmembrane proteins [8].
  • Transcripts most likely start in front of or within the 3.2 Mb region of YLII-related sequences, pass through subsequent blocks of 1.2 and 0.3 Mb of YLI- and rally-related sequences, respectively, and cease within the region of a smaller block of YLI-related repeats [21].

Analytical, diagnostic and therapeutic context of Ten-a

  • The gene is transcribed as a single mRNA (approx. 1.2 ) as determined by Northern blot hybridization [22].
  • The frequency of spontaneous miniature end plate potentials in venom treated nerve-muscle preparation falls rapidly after treatment, while the m.e.p.p. amplitude decreases to about 50% after 6 min of treatment with 1.2 X 10(-5) g of the venom per ml [23].
  • Determination of the analytes in spiked river water samples by use of the dmAChE biosensor resulted in recoveries from 50 to 90 % for chlorpyrifos oxon at levels of 20 to 40 nmol L(-1), 50 to 100 % for paraoxon at 0.6 to 0.8 micro mol L(-1), and 140 to 190 % for malaoxon at 0.6 to 1.2 micro mol L(-1) [24].


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  3. Effects of transposable element insertions on RNA encoded by the white gene of Drosophila. Levis, R., O'Hare, K., Rubin, G.M. Cell (1984) [Pubmed]
  4. Sequence requirements for function of the Drosophila chorion gene locus ACE3 replicator and ori-beta origin elements. Zhang, H., Tower, J. Development (2004) [Pubmed]
  5. Interspecific comparison of a Drosophila gene encoding FMRFamide-related neuropeptides. Taghert, P.H., Schneider, L.E. J. Neurosci. (1990) [Pubmed]
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  8. Expression of Drosophila Ten-a, a dimeric receptor during embryonic development. Fascetti, N., Baumgartner, S. Mech. Dev. (2002) [Pubmed]
  9. Phylogenetic analysis of teneurin genes and comparison to the rearrangement hot spot elements of E. coli. Minet, A.D., Chiquet-Ehrismann, R. Gene (2000) [Pubmed]
  10. Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation. Harum, K.H., Alemi, L., Johnston, M.V. Neurology (2001) [Pubmed]
  11. Strong regional heterogeneity in base composition evolution on the Drosophila x chromosome. Ko, W.Y., Piao, S., Akashi, H. Genetics (2006) [Pubmed]
  12. A physical map of the polytenized region (101EF-102F) of chromosome 4 in Drosophila melanogaster. Locke, J., Podemski, L., Aippersbach, N., Kemp, H., Hodgetts, R. Genetics (2000) [Pubmed]
  13. Retrotransposon-like sequences are expressed in Y chromosomal lampbrush loops of Drosophila hydei. Huijser, P., Kirchhoff, C., Lankenau, D.H., Hennig, W. J. Mol. Biol. (1988) [Pubmed]
  14. Regulation of choline acetyltransferase/lacZ fusion gene expression in putative cholinergic neurons of Drosophila melanogaster. Kitamoto, T., Ikeda, K., Salvaterra, P.M. J. Neurobiol. (1995) [Pubmed]
  15. Immunocytochemical study of choline acetyltransferase in Drosophila melanogaster: an analysis of cis-regulatory regions controlling expression in the brain of cDNA-transformed flies. Yasuyama, K., Kitamoto, T., Salvaterra, P.M. J. Comp. Neurol. (1995) [Pubmed]
  16. On the multiple functional roles of the active site histidine in catalysis and allosteric regulation of Escherichia coli glucosamine 6-phosphate deaminase. Montero-Morán, G.M., Lara-González, S., Alvarez-Añorve, L.I., Plumbridge, J.A., Calcagno, M.L. Biochemistry (2001) [Pubmed]
  17. Increased inwardly rectifying potassium currents in HEK-293 cells expressing murine transient receptor potential 4. Zhang, Z., Tang, Y., Zhu, M.X. Biochem. J. (2001) [Pubmed]
  18. Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes. Belelli, D., Callachan, H., Hill-Venning, C., Peters, J.A., Lambert, J.J. Br. J. Pharmacol. (1996) [Pubmed]
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  22. Cloning and sequencing of proliferating cell nuclear antigen (PCNA) from the flesh fly, Sarcophaga crassipalpis, and its expression in response to cold shock and heat shock. Tammariello, S.P., Denlinger, D.L. Gene (1998) [Pubmed]
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  24. Flow-injection amperometric determination of pesticides on the basis of their inhibition of immobilized acetylcholinesterases of different origin. Jeanty, G., Wojciechowska, A., Marty, J.L., Trojanowicz, M. Analytical and bioanalytical chemistry. (2002) [Pubmed]
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