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Gene Review

Clic  -  Chloride intracellular channel

Drosophila melanogaster

Synonyms: CG10997, DCLIC, DmCLIC, Dmel\CG10997, clic, ...
 
 
 
 
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High impact information on Clic

  • This domain, which we term the ''PTM'' domain, named after an amphipathic putative transmembrane helix contained within it, directs distinct C. elegans CLIC homologs to distinct subcellular membranes [1].
  • We find that within the PTM region, the cysteine residues required for GST-type activity are unnecessary for invertebrate CLIC function, but that specific residues within the proposed transmembrane helix are necessary for correct targeting and protein function [1].

References

 
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