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Gene Review

EP1  -  EP1

Cotesia congregata bracovirus

 
 
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Disease relevance of EP1

  • The amplified molecule is different from the EP1 chromosomally integrated form and is not encapsidated into virus particles [1].
 

High impact information on EP1

  • Unexpectedly, an off-size fragment formerly used to diagnose the integration of the EP1 sequence into wasp genomic DNA was found to be amplified in female wasps undergoing virus replication [1].
  • This cDNA hybridized to DNA of the CcPDV genome, but not to DNA isolated from M. sexta larvae, suggesting that EP1 is a CcPDV gene product [2].
  • One of these proteins, early-expressed protein 1 (EP1), is a 190-kDa molecule which constitutes up to 5% of the total hemolymph protein by 24 hr following oviposition by the wasp [2].

References

  1. Polydnavirus replication: the EP1 segment of the parasitoid wasp Cotesia congregata is amplified within a larger precursor molecule. Pasquier-Barre, F., Dupuy, C., Huguet, E., Monteiro, F., Moreau, A., Poirié, M., Drezen, J.M. J. Gen. Virol. (2002) [Pubmed]
  2. An abundantly expressed hemolymph glycoprotein isolated from newly parasitized Manduca sexta larvae is a polydnavirus gene product. Harwood, S.H., Grosovsky, A.J., Cowles, E.A., Davis, J.W., Beckage, N.E. Virology (1994) [Pubmed]
 
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