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Gene Review

Lcch3  -  Ligand-gated chloride channel homolog 3

Drosophila melanogaster

Synonyms: CG17336, CT38330, DmGABAbeta, DmGA_b, Dmel\CG17336, ...
 
 
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High impact information on Lcch3

  • Other ionotropic receptor subunits (LCCH3 and GRD) form GABA-gated cation channels when heterologously expressed [1].
  • Our data suggest that heteromultimeric channels composed of GRD and LCCH3 subunits form GABA-gated cation channels in insects [2].
  • This approach yielded three discrete amplified sequence elements (designated LCCH1, LCCH2, and LCCH3) that contained open reading frames and > 40% amino acid sequence identity to the corresponding regions of vertebrate ligand-gated chloride channel genes [3].
  • LCCH3 was localized by in situ hybridization to cytogenetic region 13F on the X chromosome.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
 

Anatomical context of Lcch3

  • Using a systematic expression screening approach, we found that the Drosophila ligand-gated ion channel subunits GRD and LCCH3 combine to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes [2].

References

  1. Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides. Buckingham, S.D., Biggin, P.C., Sattelle, B.M., Brown, L.A., Sattelle, D.B. Mol. Pharmacol. (2005) [Pubmed]
  2. Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels. Gisselmann, G., Plonka, J., Pusch, H., Hatt, H. Br. J. Pharmacol. (2004) [Pubmed]
  3. PCR-based homology probing reveals a family of GABA receptor-like genes in Drosophila melanogaster. Henderson, J.E., Knipple, D.C., Soderlund, D.M. Insect Biochem. Mol. Biol. (1994) [Pubmed]
 
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