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Gene Review

vap  -  vacuolar peduncle

Drosophila melanogaster

Synonyms: CG9209, D-RasGAP, Dmel\CG9209, RAS-GAP, RasGAP, ...
 
 
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High impact information on vap

  • Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap [1].
  • Further, lethal insertions in replication factor complex 4 (rfc4) and GTPase-activating protein 1 (Gap1) exhibit specific mitotic chromosome defects, discovering previously unknown roles for these proteins in chromosome inheritance [2].

References

  1. Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. Botella, J.A., Kretzschmar, D., Kiermayer, C., Feldmann, P., Hughes, D.A., Schneuwly, S. Mol. Biol. Cell (2003) [Pubmed]
  2. Identification of chromosome inheritance modifiers in Drosophila melanogaster. Dobie, K.W., Kennedy, C.D., Velasco, V.M., McGrath, T.L., Weko, J., Patterson, R.W., Karpen, G.H. Genetics (2001) [Pubmed]
 
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