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Gene Review:

Tcat1 - Tongue tumor resistance QTL 1

Rattus norvegicus

Synonyms: Rtc1, Ttr1

Tanuma, J. et al., Kitano, M.

Kitano,

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High impact information on Tcat1

Possible candidate genes for Stc1 and Rtc1 are discussed [1].
On the other hand, WF rats had a semidominant gene (Rtc1) mapped between D1Mit1 and D1Mit3, approximately 20 cM from D1Mit1, with a peak lod score of 3.30 for both the number of large TCs and the DTCmax [1].
In contrast, WF rats had a semidominant resistance gene, Rtc1, closely linked with D1Rat320 on chromosome 1, which is syntenic to human chromosome 11 [2].

References

Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Tanuma, J., Shisa, H., Hiai, H., Higashi, S., Yamada, Y., Kamoto, T., Hirayama, Y., Matsuuchi, H., Kitano, M. Cancer Res. (1998) [Pubmed]
Host genes controlling the susceptibility and resistance to squamous cell carcinoma of the tongue in a rat model. Kitano, M. Pathol. Int. (2000) [Pubmed]

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