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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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RAC2  -  ras-related C3 botulinum toxin substrate 2...

Bos taurus

 
 
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High impact information on RAC2

  • The Rac proteins, Rac1 and Rac2, are essential components of the NADPH oxidase system of phagocytes and regulate the actin assembly associated with membrane ruffling [1].
  • SmgGDS was able to stimulate the incorporation of guanosine 5'-[gamma-thio]-triphosphate GTP[gamma S] into the RhoA, Rac2, Rac1, Rap1A and CDC42Hs GTP-binding proteins, but the activity was greatest toward RhoA and Rac2 [1].
  • Comparative Western blotting of these proteins in human and bovine neutrophil cytosol demonstrated that Rac2 was the predominant Rac species and that D4-GDI was the predominant GDI species in bovine neutrophil cytosol [2].
  • These findings suggest that Rac2 does play a role in bovine neutrophil activation [2].
  • We also showed by subcellular fractionation techniques that Rac2 is localized primarily to the cytosolic compartment of resting bovine neutrophils, but is translocated to the plasma membrane after stimulation with PMA [2].

References

  1. SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism. Chuang, T.H., Xu, X., Quilliam, L.A., Bokoch, G.M. Biochem. J. (1994) [Pubmed]
  2. Cloning and characterization of bovine low molecular weight GTPases (Rac1 and Rac2) and rho GDP-dissociation inhibitor 2 (D4-GDI). Davis, A.R., Clements, M.K., Bunger, P.L., Siemsen, D.W., Quinn, M.T. Vet. Immunol. Immunopathol. (2000) [Pubmed]
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