Disease relevance of TBCA

• Immunization with NP-coupled protein in CFA does elicit an intense Arthus reaction when mice are challenged with the hapten 8 days later [1].
• The capacity of intrarenal injections of bovine gamma-globulin (BGG) to elicit hypersensitivity reactions was studied in guinea pigs immunized with DNP BGG or BGG immune complexes in CFA or in rats immunized with BGG in CFA [2].
• All rabbits immunized with S82 and CFA developed both antibodies and experimental allergic encephalomyelitis [3].
• Following the i.p. challenge of a shocking dose of BSA from 9 days up to 133 days after the s.c. injection of BSA in CFA, fatal anaphylaxis was induced regularly in female ICR mice that had been given the immunizing antigen when 8 weeks old [4].
• Five strains of enterotoxigenic E. coli (ETEC) producing fimbrial antigens which cause mannose-resistant haemagglutination of bovine erythrocytes (MRHA+bov) were selected among a collection of ETEC strains of the O 6 serogroup with CFA/II-like fimbrial haemagglutinins for this study [5].

High impact information on TBCA

• In addition to mediating agglutination of bovine erythrocytes, CFA/I also mediates agglutination of human erythrocytes [6].
• The percentage of CD23+ lymph node cells was increased in both BCII/CFA- and CFA-immunized mice at 1, 3, and 7 wk after immunization compared with unimmunized mice, indicating a role for the adjuvant to trigger general inflammation and CD23 expression [7].
• Lewis rats receiving 4-5 x 10(7) guinea pig (GP) myelin basic protein (MBP)-activated lymph node T cell blasts from GPMBP/CFA sensitized donors routinely show clinical signs of disease 5-6 days post transfer [8].
• The short-term thrombogenicity, patency, and stability of bovine arterial grafts, altered by a dye-mediated photo-oxidation process, was evaluated in the canine common femoral vein (CFV) and artery (CFA) model [9].
• These changes in conduction were comparable to those observed in rats immunized with myelin/CFA to induce active EAN [10].

Anatomical context of TBCA

• IFA and CFA promoted a long-lasting increase in skinfold thickness, and a mixed histological picture of PMNs and macrophages; later in the response, especially to CFA, giant cells and some lymphocytes occurred [11].

Analytical, diagnostic and therapeutic context of TBCA

• A single intraperitoneal injection of CII in IFA prevented arthritis when given at the time of immunization with CII in CFA and reduced disease severity when given at the time of arthritis onset [12].
• METHODS: CIA was induced in DBA/1J mice by an intradermal injection of 100 microl of an emulsion of bovine type II collagen (CII; 100 microg) in Freund's complete adjuvant (CFA) at the base of the tail [13].
• Intravenous injection of bovine serum albumin (BSA) into the BSA/CFA-primed ICR mice specifically induced anaphylactic death within 1 h [14].

References