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pcm  -  pacman

Drosophila melanogaster

Synonyms: CG3291, DmXrn1, Dmel\CG3291, Pcm, XRN1, ...
 
 
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High impact information on pcm

  • The RNA-induced silencing complex component Argonaute2 and orthologues of LSm4 and Xrn1 (Pacman) associated with 5'-3' mRNA degradation localize to some GWBs [1].
  • During early embryonic syncytial nuclear divisions, pcm transcripts are homogenously distributed. pcm mRNA is expressed abundantly and ubiquitously throughout the embryo during gastrulation, with high levels in the germ band and head structures [2].
  • A Kin I-dependent Pacman-flux mechanism for anaphase A [3].
  • The Pacman model posits that chromatids induce the depolymerization of microtubule plus-ends embedded in kinetochores, thereby 'chewing' their way poleward [3].
 

Analytical, diagnostic and therapeutic context of pcm

  • In situ hybridization analysis revealed that the pcm transcripts are maternally derived, and are expressed at high levels in nurse cells [2].

References

  1. Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development. Schneider, M.D., Najand, N., Chaker, S., Pare, J.M., Haskins, J., Hughes, S.C., Hobman, T.C., Locke, J., Simmonds, A.J. J. Cell Biol. (2006) [Pubmed]
  2. Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster. Till, D.D., Linz, B., Seago, J.E., Elgar, S.J., Marujo, P.E., Elias, M.L., Arraiano, C.M., McClellan, J.A., McCarthy, J.E., Newbury, S.F. Mech. Dev. (1998) [Pubmed]
  3. A Kin I-dependent Pacman-flux mechanism for anaphase A. Sharp, D.J., Rogers, G.C. Cell Cycle (2004) [Pubmed]
 
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