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Gene Review

Lphn1  -  latrophilin 1

Mus musculus

Synonyms: 2900070I05Rik, AI182398, CIRL-1, CLIBA, Calcium-independent alpha-latrotoxin receptor 1, ...
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Disease relevance of Lphn1

  • Functionally, IgG1-Lec 2 and IgG1-Lec 8 were comparable to wild type with respect to in vivo half-life, affinity for Fc gammaRI, and capacity for complement-mediated hemolysis [1].
  • This was partially purified and proved indistinguishable from the natural toxin with respect to its molecular mass, immunostaining, toxicity to mice, binding to alpha-latrotoxin receptors (latrophilin or neurexin Ialpha) and electrophysiological recording in the mouse diaphragm [2].
  • CHOP2 cells, a subline of the Chinese hamster ovary (CHO) cell glycosylation mutant Lec2 which expresses polyoma virus large T antigen, was used as the host cell line to select cDNAs conferring resistance to the toxic effects of ricin [3].

High impact information on Lphn1


Biological context of Lphn1

  • CHOP2 cells acquiring cDNA that either corrected the Lec2 mutation or created a Lec2/Lec1 phenotype were expected to show a selective growth advantage in ricin-containing medium [3].


  1. Effect of C2-associated carbohydrate structure on Ig effector function: studies with chimeric mouse-human IgG1 antibodies in glycosylation mutants of Chinese hamster ovary cells. Wright, A., Morrison, S.L. J. Immunol. (1998) [Pubmed]
  2. Functional expression of alpha-latrotoxin in baculovirus system. Volynski, K.E., Nosyreva, E.D., Ushkaryov, Y.A., Grishin, E.V. FEBS Lett. (1999) [Pubmed]
  3. Antisense and sense cDNA expression cloning using autonomously replicating vectors and toxic lectin selection. Cummings, L., Warren, C.E., Granovsky, M., Dennis, J.W. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  4. Expression of human glycophorin A in wild type and glycosylation-deficient Chinese hamster ovary cells. Role of N- and O-linked glycosylation in cell surface expression. Remaley, A.T., Ugorski, M., Wu, N., Litzky, L., Burger, S.R., Moore, J.S., Fukuda, M., Spitalnik, S.L. J. Biol. Chem. (1991) [Pubmed]
  5. In vivo trafficking and catabolism of IgG1 antibodies with Fc associated carbohydrates of differing structure. Wright, A., Sato, Y., Okada, T., Chang, K., Endo, T., Morrison, S. Glycobiology (2000) [Pubmed]
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