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Gene Review

ex  -  expanded

Drosophila melanogaster

Synonyms: 1270, CG4114, Dmel\CG4114, Ex, Expanded, ...
 
 
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High impact information on ex

  • Here, we show that Drosophila Merlin and Expanded are components of the Hippo signalling pathway, an emerging tumour-suppressor pathway [1].
  • Merlin, and its function as a negative regulator of growth, is conserved in Drosophila, where it functions with Expanded, a related FERM domain protein [1].
  • We find that Merlin and Expanded, similar to other components of the Hippo pathway, are required for proliferation arrest and apoptosis in developing imaginal discs [1].
  • Because of the phenotypic and structural similarities between Merlin and expanded, we asked whether Merlin and Expanded function together to regulate cell proliferation [2].
  • Further genetic analyses suggest a role for Merlin and Expanded specifically in Decapentaplegic-mediated differentiation events [2].
 

Biological context of ex

 

Anatomical context of ex

 

Regulatory relationships of ex

  • Fat modulates Salvador/Warts/Hippo pathway activity by promoting abundance and localization of Expanded protein at the apical membrane of epithelial tissues [8].
 

Other interactions of ex

  • Fat acts genetically and biochemically upstream of other Hippo pathway components such as Expanded, the Hippo and Warts kinases, and the transcriptional coactivator Yorkie [7].

References

  1. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Hamaratoglu, F., Willecke, M., Kango-Singh, M., Nolo, R., Hyun, E., Tao, C., Jafar-Nejad, H., Halder, G. Nat. Cell Biol. (2006) [Pubmed]
  2. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. McCartney, B.M., Kulikauskas, R.M., LaJeunesse, D.R., Fehon, R.G. Development (2000) [Pubmed]
  3. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Pellock, B.J., Buff, E., White, K., Hariharan, I.K. Dev. Biol. (2007) [Pubmed]
  4. Expanded: a gene involved in the control of cell proliferation in imaginal discs. Boedigheimer, M., Laughon, A. Development (1993) [Pubmed]
  5. The Tumor-Suppressor Gene fat Controls Tissue Growth Upstream of Expanded in the Hippo Signaling Pathway. Silva, E., Tsatskis, Y., Gardano, L., Tapon, N., McNeill, H. Curr. Biol. (2006) [Pubmed]
  6. Genetic and physical studies of a portion of the white locus participating in transcriptional regulation and in synapsis-dependent interactions in Drosophila adult tissues. Davison, D., Chapman, C.H., Wedeen, C., Bingham, P.M. Genetics (1985) [Pubmed]
  7. The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size. Willecke, M., Hamaratoglu, F., Kango-Singh, M., Udan, R., Chen, C.L., Tao, C., Zhang, X., Halder, G. Curr. Biol. (2006) [Pubmed]
  8. Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway. Bennett, F.C., Harvey, K.F. Curr. Biol. (2006) [Pubmed]
 
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