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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nanos1  -  nanos homolog 1 (Drosophila)

Mus musculus

Synonyms: NOS-1, Nanos homolog 1, Nos
 
 
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High impact information on Nanos1

  • The mouse Nanos proteins, Nanos2 and Nanos3, are required for germ cell development and share a highly conserved zinc-finger domain [1].
  • Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development [1].
  • nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development [2].
  • In Drosophila, maternally supplied Nanos functions in the migration of primordial germ cells (PGCs) into the gonad; in mice, zygotic genes are involved instead [3].
 

Biological context of Nanos1

  • The nanos1 gene encodes an RNA-binding protein, which contains a putative zinc-finger motif that exhibits similarity with other nanos-class genes in vertebrates and invertebrates [2].

References

  1. Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development. Suzuki, A., Tsuda, M., Saga, Y. Development (2007) [Pubmed]
  2. nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development. Haraguchi, S., Tsuda, M., Kitajima, S., Sasaoka, Y., Nomura-Kitabayashid, A., Kurokawa, K., Saga, Y. Mech. Dev. (2003) [Pubmed]
  3. Conserved role of nanos proteins in germ cell development. Tsuda, M., Sasaoka, Y., Kiso, M., Abe, K., Haraguchi, S., Kobayashi, S., Saga, Y. Science (2003) [Pubmed]
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