Gene Review:
PAG2 - pregnancy-associated glycoprotein 2
Bos taurus
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High impact information on PAG2
- Bovine PAG 2, unlike bovine PAG 1, has a catalytic center with a consensus sequence of amino acids [1].
- PAG 2 is synthesized by placental explants as a 70-kDa glycoprotein that is processed to several smaller molecules [1].
Biological context of PAG2
- Here we describe the isolation of a highly abundant cDNA (PAG 2 cDNA) that represents a second member of this gene family which is structurally related to bovine PAG 1, ovine PAG 1, and pepsin (58%, 58%, and 51% amino acid sequence identity, respectively) [1].
Analytical, diagnostic and therapeutic context of PAG2
- Western blot analysis of culture media developed with epitope-selected antibodies to PAG 2 reveals several bands ranging in apparent M(r) from 31,000-70,000, which correspond in size to the polypeptides present in the preparation used for immunization.(ABSTRACT TRUNCATED AT 250 WORDS)[1]
References
- A novel glycoprotein of the aspartic proteinase gene family expressed in bovine placental trophectoderm. Xie, S., Low, B.G., Nagel, R.J., Beckers, J.F., Roberts, R.M. Biol. Reprod. (1994) [Pubmed]
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