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Gene Review:

patA - Ca2+-ATPase

Dictyostelium discoideum AX4

Moniakis, J. et al., Matsuda, Y. et al., Moniakis, J. et al., Weissenmayer, B. et al., Böhme, R. et al.

Weissenmayer, Boeckeler, Lahrz, Mutzel,

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High impact information on patA

When Dictyostelium amoebae are adapted to grow in the presence of 80 mM CaCl2, both the patA message and protein product are up-regulated substantially [1].
Involvement of the Ca2+-ATPase PAT1 and the contractile vacuole in calcium regulation in Dictyostelium discoideum [2].
In Dictyostelium discoideum, the Ca2+-ATPase, PAT1, is localized to membranes of the contractile vacuole and its expression is upregulated substantially when the cells are grown in Ca2+-rich medium [2].
Up-regulation of expression of the gene for the Ca2+-ATPase PAT1 in conditions of Ca2+ stress was reduced by gossypol [3].
In addition, the null cells formed fruiting body in the presence of 2,5-di(tert-butyl)-1,4-hydroquinone (BHQ: a specific inhibitor of Ca2+-ATPase activity in the endoplasmic reticulum) [4].

Anatomical context of patA

A high-affinity plasma membrane Ca2+-ATPase in Dictyostelium discoideum: its relation to cAMP-induced Ca2+ fluxes [5].

References

Molecular cloning of an intracellular P-type ATPase from Dictyostelium that is up-regulated in calcium-adapted cells. Moniakis, J., Coukell, M.B., Forer, A. J. Biol. Chem. (1995) [Pubmed]
Involvement of the Ca2+-ATPase PAT1 and the contractile vacuole in calcium regulation in Dictyostelium discoideum. Moniakis, J., Coukell, M.B., Janiec, A. J. Cell. Sci. (1999) [Pubmed]
The calcineurin inhibitor gossypol impairs growth, cell signalling and development in Dictyostelium discoideum. Weissenmayer, B., Boeckeler, K., Lahrz, A., Mutzel, R. FEMS Microbiol. Lett. (2005) [Pubmed]
Analysis of the disruption mutant of the oscillin homolog gene of Dictyostelium discoideum. Matsuda, Y., Masamune, Y., Kodaira, K., Yasukawa, H. Biol. Pharm. Bull. (1999) [Pubmed]
A high-affinity plasma membrane Ca2+-ATPase in Dictyostelium discoideum: its relation to cAMP-induced Ca2+ fluxes. Böhme, R., Bumann, J., Aeckerle, S., Malchow, D. Biochim. Biophys. Acta (1987) [Pubmed]

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