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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

gcm2  -  CG3858 gene product from transcript CG3858-RA

Drosophila melanogaster

Synonyms: CG3858, Dmel\CG3858, FBgn0019809, Gcm2, Protein glide-2, ...
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High impact information on gcm2


Biological context of gcm2

  • Furthermore, we show that prohemocytes are bipotent progenitors, and that downregulation of gcm/gcm2 is required for lz-induced crystal cell formation [3].

Anatomical context of gcm2

  • Removal of gcm and gcm2 function shows that the two genes act redundantly and are required for the formation of a subset of glial cells [1].
  • Here, we show that glide/gcm and glide2/gcm2, the fly glial cell determinants, are expressed in a subpopulation of embryonic tendon cells and required for their terminal differentiation [4].
  • Our results suggest that both gcm and gcm2 are required together for the proliferation of plasmatocyte precursors, the expression of Croquemort protein, and the ability of plasmatocytes to convert into macrophages [2].


  1. glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of Drosophila. Chotard, C., Leung, W., Salecker, I. Neuron (2005) [Pubmed]
  2. gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila. Alfonso, T.B., Jones, B.W. Dev. Biol. (2002) [Pubmed]
  3. Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors. Bataillé, L., Augé, B., Ferjoux, G., Haenlin, M., Waltzer, L. Development (2005) [Pubmed]
  4. Terminal tendon cell differentiation requires the glide/gcm complex. Soustelle, L., Jacques, C., Altenhein, B., Technau, G.M., Volk, T., Giangrande, A. Development (2004) [Pubmed]
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