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Gene Review:

Gyc32E - Guanyl cyclase at 32E

Drosophila melanogaster

Synonyms: CG33114, CG6275, Cyg1, DMRGC, Dmel\CG33114, ...

Liu, H.F. et al., Rodin, S.N. et al., Kanai, M. et al.

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High impact information on Gyc32E

Here we show that the conserved proteins, MO25-like Pmo25, GC kinase Nak1, Mor2, and Orb6, constitute a morphogenesis network that is important for polarity control and cell separation [1].
In mammalian genomes, this trend is definitely associated with presumably methylated hypermutable CpG sites, and in a typical GC-asymmetric gene pair, its two member genes are embedded in GC-contrasting isochores [2].
PcGC-M2 is most closely related (33% identity) to a Drosophila membrane form GC (DrGC-1), and an Anopheles gambiae membrane form GC (AgaGC); the three GCs also share a similar distribution pattern of conserved cysteine residues in the extracellular domain [3].
Available data indicate that crustacean hyperglycemic hormone (CHH) stimulates membrane-bound guanylyl cyclase (GC), producing cyclic guanosine 3',5'-monophosphate, which in turn mediates the effect of CHH on carbohydrate metabolism [3].

References

Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis. Kanai, M., Kume, K., Miyahara, K., Sakai, K., Nakamura, K., Leonhard, K., Wiley, D.J., Verde, F., Toda, T., Hirata, D. EMBO J. (2005) [Pubmed]
Position-associated GC asymmetry of gene duplicates. Rodin, S.N., Parkhomchuk, D.V. J. Mol. Evol. (2004) [Pubmed]
Molecular cloning of a putative membrane form guanylyl cyclase from the crayfish Procambarus clarkii. Liu, H.F., Lai, C.Y., Watson, R.D., Lee, C.Y. J. Exp. Zoolog. Part A Comp. Exp. Biol. (2004) [Pubmed]

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