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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mre11  -  meiotic recombination 11

Drosophila melanogaster

Synonyms: 16928, CG16928, Dmel\CG16928, MRE11, Mre11
 
 
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High impact information on mre11

  • We conducted genetic and cytological studies on Drosophila atm and mre11 knockout mutants and discovered a telomere defect that was more severe than in any of the non-Drosophila systems studied [1].
  • The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage [2].
  • The conserved ATM checkpoint kinase and the Mre11 DNA repair complex play essential and overlapping roles in maintaining genomic integrity [1].
 

Biological context of mre11

 

Other interactions of mre11

  • Larval brain cells of nbs mutants display telomeric associations (TAs) but the frequency of these TAs is lower than in either mre11 or rad50 mutants [3].

References

  1. Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance. Bi, X., Wei, S.C., Rong, Y.S. Curr. Biol. (2004) [Pubmed]
  2. The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Ciapponi, L., Cenci, G., Ducau, J., Flores, C., Johnson-Schlitz, D., Gorski, M.M., Engels, W.R., Gatti, M. Curr. Biol. (2004) [Pubmed]
  3. The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Ciapponi, L., Cenci, G., Gatti, M. Genetics (2006) [Pubmed]
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