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Gene Review

nht  -  no hitter

Drosophila melanogaster

Synonyms: BG:DS07851.6, CG15259, DS07851.6, Dmel\CG15259, Nht, ...
 
 
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High impact information on nht

  • This 56-amino-acid activation region fails to interact with the putative Sp1 coactivator, dTAFII110, and thus appears to use a mechanism distinct from the glutamine-rich activation domain of Sp1 [1].
  • Mutations in nht, mia and sa have similar effects in primary spermatocytes on transcription of several target genes involved in spermatid differentiation, and cause the same phenotypes as mutations in can, blocking both meiotic cell cycle progression and spermatid differentiation [2].
  • The nht, mia, sa and rye proteins contain histone fold domain dimerization motifs [2].
  • To test whether transcription activation by CBF requires co-activators, we examined the interaction between CBF and dTAF110, a component of the Drosophila TFIID complex [3].

References

  1. Drosophila tissue-specific transcription factor NTF-1 contains a novel isoleucine-rich activation motif. Attardi, L.D., Tjian, R. Genes Dev. (1993) [Pubmed]
  2. Testis-specific TAF homologs collaborate to control a tissue-specific transcription program. Hiller, M., Chen, X., Pringle, M.J., Suchorolski, M., Sancak, Y., Viswanathan, S., Bolival, B., Lin, T.Y., Marino, S., Fuller, M.T. Development (2004) [Pubmed]
  3. The two activation domains of the CCAAT-binding factor CBF interact with the dTAFII110 component of the Drosophila TFIID complex. Coustry, F., Sinha, S., Maity, S.N., Crombrugghe, B. Biochem. J. (1998) [Pubmed]
 
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