High impact information on cni

• cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila [1].
• The polarity defect of erv14Delta yeast cells is reminiscent of cornichon mutants, in which egg chambers fail to establish proper asymmetry during early stages of oogenesis [2].
• During Drosophila oogenesis, Cni is required for transport of the TGFalpha growth factor Gurken (Grk) to the oocyte surface [3].
• Consequently, in the absence of Cni function, Grk fails to leave the oocyte ER [3].
• In order to characterize further the function of K10, we have analyzed its genetic interactions with grk, top and cni [4].

Biological context of cni

• As part of a large scale mouse Expressed Sequence Tag (EST) project to identify molecules involved in the initiation of mammalian development, a homolog of the Drosophila cornichon gene was detected as a mouse maternal transcript present in the two-cell embryo [5].

Anatomical context of cni

• In analogy to cni which is involved in an epidermal growth factor-like signaling pathway inducing cellular asymmetry in Drosophila oogenesis, TGAM77 might function in similar signaling establishing vectorial re-localization and concentration of signaling events in T-cell activation [6].

References