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Gene Review

Rtl1  -  retrotransposon-like 1

Mus musculus

Synonyms: 6430411K18Rik, Mammalian retrotransposon derived protein 1, Mar, Mar1, Mart1, ...
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Disease relevance of Rtl1


High impact information on Rtl1

  • A retrotransposon-like gene (Rtl1) is expressed from the paternal chromosome and has an antisense transcript expressed from the maternal chromosome containing two microRNAs with full complementarity to Rtl1 (ref. 12) [3].
  • By manipulating donor and recipient strain combinations, we permitted the Mar CD4(+) T cells to respond to the H-Y Ag after processing and presentation by recipient APCs (indirect pathway), or to the male Ag as expressed on donor APCs (direct pathway) [4].
  • Retrotransposon-like VL30 elements are efficiently induced in anoxic rat fibroblasts [5].
  • Sequence database analysis suggested that Mart genes are present in opossum (marsupial), but absent from the genome of chicken [6].
  • Most Mart genes are located on the X chromosome in different mammals [6].

Biological context of Rtl1


Anatomical context of Rtl1


Associations of Rtl1 with chemical compounds


Other interactions of Rtl1


Analytical, diagnostic and therapeutic context of Rtl1


  1. Acute and subacute toxicity of Cochlospermum regium (Mart. & Schr.) pilger. Toledo, M.I., Siqueira, J.M., Araújo, L.C., Oga, S. Phytotherapy research : PTR. (2000) [Pubmed]
  2. Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart. Gamberini, M.T., Skorupa, L.A., Souccar, C., Lapa, A.J. Mem. Inst. Oswaldo Cruz (1991) [Pubmed]
  3. Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Lin, S.P., Youngson, N., Takada, S., Seitz, H., Reik, W., Paulsen, M., Cavaille, J., Ferguson-Smith, A.C. Nat. Genet. (2003) [Pubmed]
  4. The male minor transplantation antigen preferentially activates recipient CD4+ T cells through the indirect presentation pathway in vivo. Chen, Y., Demir, Y., Valujskikh, A., Heeger, P.S. J. Immunol. (2003) [Pubmed]
  5. Retrotransposon-like VL30 elements are efficiently induced in anoxic rat fibroblasts. Anderson, G.R., Stoler, D.L., Scarcello, L.A. J. Mol. Biol. (1989) [Pubmed]
  6. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Brandt, J., Schrauth, S., Veith, A.M., Froschauer, A., Haneke, T., Schultheis, C., Gessler, M., Leimeister, C., Volff, J.N. Gene (2005) [Pubmed]
  7. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. Brandt, J., Veith, A.M., Volff, J.N. Cytogenet. Genome Res. (2005) [Pubmed]
  8. Metabolic energy dependent exocytosis of mouse mast cells by lectin of Dioclea grandiflora (Mart.). Silva Lima, M., Oliveira, M.C., Azevedo Moreira, R., Prouvost-Danon, A. Biochem. Pharmacol. (1985) [Pubmed]
  9. A study of the pharmacological actions of Dioclea grandiflora Martius ex Bentham. Mattei, R., Leite, J.R., Tufik, S. São Paulo medical journal = Revista paulista de medicina. (1995) [Pubmed]
  10. Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart.). Lima, M.S., Albuquerque, D.A., Ibañez, O.M., Sant'anna, O. Mem. Inst. Oswaldo Cruz (1993) [Pubmed]
  11. Antidiarrhoeal activity of bisnordihydrotoxiferine isolated from the root bark of Strychnos trinervis (Vell.) Mart. (Loganiaceae). Melo, M.d.e. .F., Thomas, G., Mukherjee, R. J. Pharm. Pharmacol. (1988) [Pubmed]
  12. Antiulcerogenic activity of ethanol extract of Solanum variabile (false "jurubeba"). Antonio, J.M., Gracioso, J.S., Toma, W., Lopez, L.C., Oliveira, F., Brito, A.R. Journal of ethnopharmacology. (2004) [Pubmed]
  13. Acute effects of guarana (Paullinia cupana Mart.) on mouse behaviour in forced swimming and open field tests. Campos, A.R., Barros, A.I., Albuquerque, F.A., M Leal, L.K., Rao, V.S. Phytotherapy research : PTR. (2005) [Pubmed]
  14. Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats. Campos, A.R., Barros, A.I., Santos, F.A., Rao, V.S. Phytotherapy research : PTR. (2003) [Pubmed]
  15. Regulation of yellow pigment formation in mice: a historical perspective. Wolff, G.L. Pigment Cell Res. (2003) [Pubmed]
  16. Intermediate filaments reconstituted from vimentin, desmin, and glial fibrillary acidic protein selectively bind repetitive and mobile DNA sequences from a mixture of mouse genomic DNA fragments. Tolstonog, G.V., Wang, X., Shoeman, R., Traub, P. DNA Cell Biol. (2000) [Pubmed]
  17. Effect of Maytenus ilicifolia Mart. on pregnant mice. Montanari, T., Bevilacqua, E. Contraception. (2002) [Pubmed]
  18. Trypanocidal activity of chemical constituents from Lychnophora salicifolia Mart. Jordão, C.O., Vichnewski, W., de Souza, G.E., Albuquerque, S., Lopes, J.L. Phytotherapy research : PTR. (2004) [Pubmed]
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