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Gene Review

SCAP  -  SREBP cleavage activating protein

Drosophila melanogaster

Synonyms: CG14592, CG33131, CG8356, Dmel\CG33131, Scap, ...
 
 
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High impact information on SCAP

  • Transport is blocked by cholesterol, which triggers SCAP, the SREBP escort protein, to bind to Insigs, which are ER retention proteins [1].
  • Using recombinant SCAP purified in detergent, we show that cholesterol acts by binding with high affinity and specificity to the 767 amino acid octahelical membrane region of SCAP [1].
  • Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain [1].
  • We show that the membrane domain of SCAP is a tetramer and that cholesterol binding is inhibited by cationic amphiphiles, raising the possibility of allosteric regulation by positively charged phospholipids [1].

References

  1. Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Radhakrishnan, A., Sun, L.P., Kwon, H.J., Brown, M.S., Goldstein, J.L. Mol. Cell (2004) [Pubmed]
 
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