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Gene Review

sax  -  saxophone

Drosophila melanogaster

Synonyms: Bkr43E, Brk43E, CG1891, Dmel\CG1891, SAX, ...
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High impact information on sax

  • Brk43E is the product of the gene saxophone, which also interacts with dpp [1].
  • Drosophila sequences at chromosomal positions 25D (Brk25D) and 43E (Brk43E) are similar to the TGF beta type I receptor serine/threonine kinases and are expressed broadly during embryogenesis [1].
  • Wing patterning in Drosophila requires a Bmp activity gradient created by two Bmp ligands, Gbb and Dpp, and two Bmp type I receptors, Sax and Tkv [2].

Other interactions of sax

  • Furthermore, the critical ratio of Gbb-60A to Dpp signaling appears to be mediated by both Tkv and Sax type I receptors [3].


  1. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Penton, A., Chen, Y., Staehling-Hampton, K., Wrana, J.L., Attisano, L., Szidonya, J., Cassill, J.A., Massagué, J., Hoffmann, F.M. Cell (1994) [Pubmed]
  2. Dual function of the Drosophila Alk1/Alk2 ortholog Saxophone shapes the Bmp activity gradient in the wing imaginal disc. Bangi, E., Wharton, K. Development (2006) [Pubmed]
  3. TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing. Khalsa, O., Yoon, J.W., Torres-Schumann, S., Wharton, K.A. Development (1998) [Pubmed]
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