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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rme-8  -  Receptor mediated endocytosis 8

Drosophila melanogaster

Synonyms: CG8014, Dmel\CG8014, E(shi)2-1, l(2)45Ba, rme-8
 
 
 
 
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High impact information on Rme-8

  • Indeed, biochemical and genetic data demonstrated that Rme-8 interacts specifically with Hsc70-4 via its J-domain [1].
  • The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila [1].
  • Thus, Rme-8 appears to function as an unexpected but critical cochaperone with Hsc70 in endocytosis [1].
  • The phenotypes of Rme-8 mutants bear a strong resemblance to those of Hsc70-4, suggesting that these two genes act in a common pathway [1].
  • Analysis of Drosophila Rme-8 mutants showed that internalization of Bride of sevenless and the uptake of tracers were blocked [1].

References

  1. The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila. Chang, H.C., Hull, M., Mellman, I. J. Cell Biol. (2004) [Pubmed]
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